Regulatory T cells in cancer; can they be controlled?

• Published in: Immunotherapy Vol. 7; no. 8; pp. 843 - 846
• Main Authors: Adeegbe, Dennis O, Nishikawa, Hiroyoshi
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.08.2015
• Subjects: Antigens; Biomarkers, Tumor - immunology; Biomarkers, Tumor - metabolism; Cancer; Cancer treatment; Chemokines; Cytokines - immunology; Cytokines - metabolism; function; Genotype & phenotype; Health aspects; Humans; immune checkpoint; Immune response regulation; immunotherapy; Lymphocyte Activation - immunology; Lymphocytes; Lymphocytes, Tumor-Infiltrating - immunology; Lymphocytes, Tumor-Infiltrating - metabolism; Medical research; Methods; microenvironment; Neoplasms - immunology; Neoplasms - metabolism; recruitment; regulatory T cell; Rodents; T cell receptors; T cells; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; TCR diversity; Tumor Microenvironment - immunology; tumor-associated antigen; microenvironment; recruitment; function; immune checkpoint; immunotherapy; cancer; TCR diversity; regulatory T cell; tumor-associated antigen; chemokines
• ISSN: 1750-743X; 1750-7448
• DOI: 10.2217/imt.15.52

Furthermore, they may act in tandem with other suppressor types such as myeloid-derived suppressor cells, posing a barrier to efficient infiltration of effector T cells [13]. [...]Treg cell dampening of antitumor T-cell responses may be orchestrated in series of direct and indirect events involving multiple cell types. While the former can be upregulated on activated T cells, the increased expression of the latter is only confined to Treg cells upon activation and has been suggested to play a role in Treg-cell function [20]. [...]for therapeutic purposes, attention should be paid to the distinct features exhibited by tumor-infiltrating Treg cells (Figure 1).