Relationship between the Arg72Pro polymorphism of p53 and outcome for patients with traumatic brain injury

• Published in: Intensive care medicine Vol. 31; no. 9; pp. 1168 - 1173
• Main Authors: MARTINEZ-LUCAS, Pascual, MORENO-CUESTA, Jeronimo, GARCIA-OLMO, Dolores C, SANCHEZ-SANCHEZ, Francisco, ESCRIBANO-MARTINEZ, Julio, DEL POZO, Ana Cuartero, LIZAN-GARCIA, Maxima, GARCIA-OLMO, Damian
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.09.2005; Berlin Springer Nature B.V
• Subjects: Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; APACHE; Biological and medical sciences; Brain; Brain Injuries - classification; Brain Injuries - genetics; Brain Injuries - mortality; Care and treatment; Case studies; Dipeptides - genetics; Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care; Female; Genes, p53 - genetics; Genetic polymorphisms; Genotype; Humans; Injuries; Injuries of the nervous system and the skull. Diseases due to physical agents; Injury Severity Score; Intensive care medicine; Intensive Care Units; Male; Medical sciences; Polymorphism, Single Nucleotide; Predictive Value of Tests; Prospective Studies; Spain; Traumas. Diseases due to physical agents; Tumor proteins; Spain; United States; Human; Nervous system diseases; Intensive care; Prognosis; Central nervous system; Glasgow Outcome Scale; Encephalon; p53; Head trauma; Single nucleotide polymorphism; Resuscitation; Brain injury; Polymorphism
• ISSN: 0342-4642; 1432-1238
• DOI: 10.1007/s00134-005-2715-0

To determine the relationship between the Arg72Pro polymorphism of p53 and the outcome after traumatic brain injury (TBI) in humans. A prospective study was carried out in a ten-bed surgical intensive care unit (SICU) of a university hospital. The study included 90 caucasian patients who had experienced a severe TBI within the previous 24 h. The exclusion criterion was a previous deficit in the central nervous system. The main recorded outcomes were values on the Glasgow Outcome Scale (GOS) at discharge from the SICU (GOS-0) and 6 months later (GOS-6). A blood sample was taken from each patient and all samples were analyzed by an allele-specific polymerase chain reaction for detection of Arg72Pro polymorphism of p53. These polymorphisms were tested for their association with values of GOS-0 and GOS-6. A two-tailed value of p<0.05 was considered statistically significant. The frequency of the argine/argine (Arg/Arg) genotype was greater among the patients who had a bad outcome at GOS-0 (69 vs 31% in the bad-outcome group; p=0.029). A multiple logistic regression analysis showed that patients with the Arg/Arg variation had a 2.9-fold greater risk of having a bad outcome at discharge from the SICU (95% confidence interval, 1.05-8.31; p=0.039 ). There was no similar relationship with respect to GOS-6. The Arg/Arg genotype of the Arg72Pro polymorphism in p53 is associated with increased likelihood of a bad outcome at discharge from the SICU.