Efficacy of Topical 5% Acyclovir-1% Hydrocortisone Cream (ME-609) for Treatment of Herpes Labialis: a systematic review

We performed a systematic review with the objective of verifying the efficacy of topical use 5% Acyclovir-1% Hydrocortisone cream compared to the placebo group for herpes simplex labialis treatment. We performed a literature search using MEDLINE, Embase, BIOSIS, LILACS, Scopus, Grey literature, the...

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Published inAnais da Academia Brasileira de Ciências Vol. 87; no. 2 Suppl; pp. 1415 - 1420
Main Authors Rosa, Maria Inês da, Souza, Suéli L, Farias, Bruna F de, Pires, Patrícia D S, Dondossola, Eduardo R, dos Reis, Maria Eduarda F
Format Journal Article
LanguageEnglish
Portuguese
Published Brazil Academia Brasileira de Ciências 01.08.2015
Subjects
aciclovir
Acyclovir - administration & dosage
Administration, Topical
Anti-Inflammatory Agents - administration & dosage
Antiviral Agents - administration & dosage
Drug Combinations
herpes labial
Herpes Labialis - drug therapy
hidrocortisona
Humans
Hydrocortisone - administration & dosage
ME-609
MULTIDISCIPLINARY SCIENCES
Randomized Controlled Trials as Topic
Revisão Sistemática
hidrocortisona
Revisão Sistemática
Systematic Review
aciclovir
herpes labial
Herpes Labialis
Acyclovir
Hydrocortisone
ME-609
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Summary:We performed a systematic review with the objective of verifying the efficacy of topical use 5% Acyclovir-1% Hydrocortisone cream compared to the placebo group for herpes simplex labialis treatment. We performed a literature search using MEDLINE, Embase, BIOSIS, LILACS, Scopus, Grey literature, the Cochrane Central Register of Controlled Trials, the ISI Web of Science and IBECS from 1990 to June 2014. We reported the outcomes using relative risk (RR) with 95% confidence intervals. The literature search yielded 180 potentially relevant publications. Reviews of the reference lists yielded two further citations. Among these papers, two were considered eligible for inclusion in this review. Both trials included 1,213 patients. A meta-analysis of these studies showed a RR = 0.77, (95% CI 0.70-0.86; p<0.001).This result suggests that an early episodic treatment with the combination of an antiviral and a steroid is beneficial for herpes simplex labialis treatment.
Bibliography:SourceType-Scholarly Journals-1
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ObjectType-Undefined-1
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ISSN:0001-3765
1678-2690
1678-2690
DOI:10.1590/0001-3765201520140701