NRF2 in Viral Infection

The transcription factor NRF2 is central to redox homeostasis in animal cells and is a well-known driver of chemoresistance in many types of cancer. Recently, new roles have been ascribed to NRF2 which include regulation of antiviral interferon responses and inflammation. In addition, NRF2 is emergi...

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Bibliographic Details
Published inAntioxidants Vol. 10; no. 9; p. 1491
Main Authors Herengt, Angela, Thyrsted, Jacob, Holm, Christian K.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 18.09.2021
MDPI
Subjects
Antioxidants
Chemoresistance
HIV
Homeostasis
Human immunodeficiency virus
immunology
Infections
Interferon
Kinases
Metabolism
Neuroblastoma
NRF2
Phosphorylation
Proteins
Regulation
Respiratory syncytial virus
Review
Transcription factors
Viral infections
virus
Viruses
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Summary:The transcription factor NRF2 is central to redox homeostasis in animal cells and is a well-known driver of chemoresistance in many types of cancer. Recently, new roles have been ascribed to NRF2 which include regulation of antiviral interferon responses and inflammation. In addition, NRF2 is emerging as an important factor in antiviral immunity through interferon-independent mechanisms. In the review, we give an overview of the scientific progress on the involvement and importance of NRF2 in the context of viral infection.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox10091491