The art and design of genetic screens: zebrafish

Inventive genetic screens in zebrafish are revealing new genetic pathways that control vertebrate development, disease and behaviour. By exploiting the versatility of zebrafish, biological processes that had been previously obscured can be visualized and many of the responsible genes can be isolated...

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Bibliographic Details
Published inNature reviews. Genetics Vol. 2; no. 12; pp. 956 - 966
Main Authors Zon, Leonard I, Patton, E. Elizabeth
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.12.2001
Subjects
Animals
Cell cycle
Embryos
Genes
Genetic engineering
Genome
Haploidy
Homozygote
Mutation
Zebrafish
Zebrafish - genetics
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Summary:Inventive genetic screens in zebrafish are revealing new genetic pathways that control vertebrate development, disease and behaviour. By exploiting the versatility of zebrafish, biological processes that had been previously obscured can be visualized and many of the responsible genes can be isolated. Coupled with gene knockdown and overexpression technologies, and small-molecule-induced phenotypes, genetic screens in zebrafish provide a powerful system by which to dissect vertebrate gene function and gene networks.
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ISSN:1471-0056
1471-0064
DOI:10.1038/35103567