Novel Options to Counteract Oral Biofilm Formation: In Vitro Evidence

Biofilm production on biotic and abiotic surfaces is crucial in the pathogenesis of most infections, particularly those occurring in the oral cavity. Its prevention and/or control may greatly facilitate the management of patients with oral diseases. Here, the antibiofilm activity of a biomimetic hyd...

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Bibliographic Details
Published inInternational journal of environmental research and public health Vol. 19; no. 13; p. 8056
Main Authors Odorici, Alessandra, Colombari, Bruna, Bellini, Pierantonio, Meto, Aida, Venturelli, Irene, Blasi, Elisabetta
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 30.06.2022
MDPI
Subjects
Antimicrobial agents
Biofilms
Communication
Drug dosages
Drug resistance
Homeostasis
Hydroxyapatite
Oral hygiene
Pathogens
Statistical analysis
Italy
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Summary:Biofilm production on biotic and abiotic surfaces is crucial in the pathogenesis of most infections, particularly those occurring in the oral cavity. Its prevention and/or control may greatly facilitate the management of patients with oral diseases. Here, the antibiofilm activity of a biomimetic hydroxyapatite and a natural compound, MicroRepair (MicroR) and pomegranate (PomeGr), respectively, was assessed. By luminescence/fluorescence-based assays, Pseudomonas aeruginosa (P. aeruginosa), Staphylococcus aureus (S. aureus) and Candida albicans (C. albicans) were tested for biofilm production in the presence of MicroR and/or PomeGr. We found that both MicroR and PomeGr could affected biofilm production; however, the efficacy of the two, given alone or in combination, varied according to the microbial agent considered. These data open to clinical studies aimed at defining the most efficacious protocols to counteract oral biofilm-associated infections.
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ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph19138056