Effect of Exercise Intervention on Endothelial Function and Incidence of Cardiovascular Disease in Patients with Type 2 Diabetes

• Published in: Journal of Atherosclerosis and Thrombosis Vol. 17; no. 8; pp. 828 - 833
• Main Authors: Yoshimasa, Yasunao, Takaki, Hiroshi, Makino, Hisashi, Nagumo, Ayako, Miyamoto, Yoshihiro, Hiuge, Aki, Konishi, Harumi, Goto, Yoichi, Okada, Sadanori
• Format: Journal Article
• Language: English
• Published: Japan Japan Atherosclerosis Society 01.01.2010
• Subjects: Aged; Blood Glucose - metabolism; Blood Pressure; Cardiovascular Diseases - etiology; Cardiovascular Diseases - metabolism; Cardiovascular Diseases - therapy; Cardiovascular events; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - therapy; Endothelial function; Endothelium, Vascular - metabolism; Exercise; Exercise Therapy; Female; Follow-Up Studies; Glycated Hemoglobin A - metabolism; Humans; Incidence; Insulin Resistance; Male; Middle Aged; Type 2 diabetes; Vasodilation - physiology
• ISSN: 1340-3478; 1880-3873; 1880-3873
• DOI: 10.5551/jat.3798

Aim: The effects of exercise intervention and to assess its long-term efficacy in preventing subsequent cardiovascular events in patients with type 2 diabetes were little known on randomized controlled trial. Methods: Thirty-eight type 2 diabetic patients (21 men and 17 women) were assigned to either the exercise group (n=21) or the control group without exercise training (n=17) by simple randomization. The exercise training group was scheduled for aerobic and resistance exercise programs for 3 months. After the 3-month, we investigated endothelial function, insulin resistance, adipocytokines and inflammatory markers. The endothelial function was evaluated by examining a flow-mediated endothelium-dependent vasodilatation (FMD). Furthermore, we followed the incidence of cardiovascular events for 24 months. Results: After 3-month, HbA1C was decreased significantly in both groups. FMD was increased from 7.3±4.7% to 10.9±6.2% only in the exercise group (p<0.05). Long-term follow-up data showed that the control group developed cardiovascular events more frequently than did the exercise group (p<0.05). Conclusions: Exercise improves endothelial dysfunction independently of glycemic control and insulin sensitivity in patients with type 2 diabetes. The beneficial effects of 3-month exercise to reduce cardiovascular events persist for 24 months.