Antioxidant activities of polysaccharides from Hyriopsis cumingii

• Published in: Carbohydrate polymers Vol. 78; no. 2; pp. 199 - 204
• Main Authors: Qiao, Deliang, Ke, Chunling, Hu, Bing, Luo, Jianguang, Ye, Hong, Sun, Yi, Yan, Xiaoyan, Zeng, Xiaoxiong
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 05.09.2009; Elsevier
• Subjects: Antioxidant activity; Applied sciences; Biological and medical sciences; China; Exact sciences and technology; free radical scavengers; Free radicals; functional foods; General and cellular metabolism. Vitamins; Hyriopsis cumingii; In vitro; in vitro studies; In vivo; in vivo studies; Medical sciences; medicinal properties; mussels; Natural polymers; Pharmacology. Drug treatments; Physicochemistry of polymers; Polysaccharides; Starch and polysaccharides; China; In vivo; Hyriopsis cumingii; Polysaccharides; Free radicals; In vitro; Antioxidant activity; Metal ion; Radical trapping; Chinese medicine; Binding capacity; Scavenging efficiency; Folk medicine; Bivalvia; DPPH; Rodentia; Animal origin; Antioxidant; Experimental study; Biological activity; Vertebrata; Iron III; Mammalia; Mouse; Animal; Hydroperoxy radicals; Oside polymer; Superoxide radicals; Invertebrata; Mollusca; Unionidae
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2009.03.018

The antioxidant activities of crude Hyriopsis cumingii polysaccharides (HCPS) were evaluated both in vitro and in vivo. In vitro antioxidant assay, HCPS (crude and its purified fraction) could scavenge hydrogen peroxide, free radicals of superoxide anion and 2,2-diphenyl-1-picryl-hydrazyl, chelate ferrous ion and reduce ferric ion. Except for metal ion chelating activity, HCPS-3 exhibited much higher antioxidant activities than crude HCPS, HCPS-1 and HCPS-2. For antioxidant testing in vivo, different doses of crude HCPS were orally administrated over a period of 15 days in a d-galactose induced aged mice model. As results, administration of crude HCPS inhibited significantly the formation of malondialdehyde in mice livers and serums and raised the activities of antioxidant enzymes and total antioxidant capacity in a dose-dependent manner. The results suggested that HCPS had direct and potent antioxidant activities.