Single-Dose Gadoterate Meglumine for 3T Late Gadolinium Enhancement MRI for the Assessment of Chronic Myocardial Infarction: Intra-Individual Comparison with Conventional Double-Dose 1.5T MRI

• Published in: Korean journal of radiology Vol. 19; no. 3; pp. 372 - 380
• Main Authors: Lim, Jiyeon, Park, Eun-Ah, Song, Yong Sub, Lee, Whal
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society of Radiology 01.05.2018; 대한영상의학회
• Subjects: Adult; Aged; Cardiovascular Imaging; Chronic Disease; Contrast Media - chemistry; Female; Heart attacks; Humans; Magnetic fields; Magnetic Resonance Imaging; Male; Meglumine - chemistry; Middle Aged; Myocardial Infarction - diagnosis; Myocardial Infarction - diagnostic imaging; Organometallic Compounds - chemistry; Patients; Radiographic Image Enhancement; Reproducibility; Signal-To-Noise Ratio; 방사선과학; Gadolinium contrast agent; Magnetic resonance imaging; Chronic myocardial infarction; Late gadolinium enhancement
• ISSN: 1229-6929; 2005-8330
• DOI: 10.3348/kjr.2018.19.3.372

To intra-individually compare 3T magnetic resonance (MR) images obtained with one dose gadoterate meglumine to 1.5T MR using conventional double dose for assessment of chronic myocardial infarction. Sixteen patients diagnosed with chronic myocardial infarctions were examined on single-dose 3T MR within two weeks after undergoing double-dose 1.5T MR. Representative short-axis images were acquired at three points after administration of gadoterate meglumine. Contrast-to-noise ratios between infarcted and normal myocardium (CNR ) and between infarct and left ventricular cavity (CNR ) were calculated and compared intra-individually at each temporal scan. Additionally, two independent readers assessed relative infarct size semi-automatically and inter-observer reproducibility was evaluated using intraclass correlation coefficient. While higher CNR was revealed at single-dose 3T at only 10 minutes scan ( = 0.047), the CNR was higher at single-dose 3T MR at each temporal scan (all, < 0.05). Measurement of relative infarct size was not significantly different between both examinations for both observers (all, > 0.05). However, inter-observer reproducibility was higher at single-dose 3T MR (all, < 0.05). Single-dose 3T MR is as effective as double-dose 1.5T MR for delineation of infarcted myocardium while being superior in detection of infarcted myocardium from the blood cavity, and provides better reproducibility for infarct size quantification.