Genetic Predisposition to External Apical Root Resorption in Orthodontic Patients: Linkage of Chromosome-18 Marker

External apical root resorption (EARR) is a common orthodontic treatment sequela. Previous studies implicate a substantial genetic component for EARR. Using a candidate gene approach, we investigated possible linkage of EARR associated with orthodontic treatment with the TNSALP, TNF α , and TNFRSF11...

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Published inJournal of dental research Vol. 82; no. 5; pp. 356 - 360
Main Authors Al-Qawasmi, R.A., Hartsfield, J.K., Everett, E.T., Flury, L., Liu, L., Foroud, T.M., Macri, J.V., Roberts, W.E.
Format Journal Article
LanguageEnglish
Published United States SAGE Publications 01.05.2003
SAGE PUBLICATIONS, INC
Subjects
Child
Chromosomes, Human, Pair 18 - genetics
Dentistry
Female
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease - genetics
Glycoproteins - genetics
Humans
Male
Malocclusion - therapy
Microsatellite Repeats
Orthodontics, Corrective - adverse effects
Osteoprotegerin
Pedigree
Polymorphism, Genetic
Receptors, Cytoplasmic and Nuclear - genetics
Receptors, Tumor Necrosis Factor
Root Resorption - etiology
Root Resorption - genetics
Siblings
Statistics, Nonparametric
orthodontics
RANK
root resorption
linkage
chromosome 18
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Summary:External apical root resorption (EARR) is a common orthodontic treatment sequela. Previous studies implicate a substantial genetic component for EARR. Using a candidate gene approach, we investigated possible linkage of EARR associated with orthodontic treatment with the TNSALP, TNF α , and TNFRSF11A gene loci. The sample was comprised of 38 American Caucasian families with a total of 79 siblings who completed comprehensive orthodontic treatment. EARR was assessed by means of pre- and post-treatment radiographs. Buccal swab cells were collected for extraction and analysis of DNA. No evidence of linkage was found with EARR and the TNF α and TNSALP genes. Non-parametric sibling pair linkage analysis identified evidence of linkage (LOD = 2.5; p = 0.02) of EARR affecting the maxillary central incisor with the microsatellite marker D18S64 (tightly linked to TNFRSF11A). This indicates that the TNFRSF11A locus, or another tightly linked gene, is associated with EARR.
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ISSN:0022-0345
1544-0591
DOI:10.1177/154405910308200506