Genetic Predisposition to External Apical Root Resorption in Orthodontic Patients: Linkage of Chromosome-18 Marker
External apical root resorption (EARR) is a common orthodontic treatment sequela. Previous studies implicate a substantial genetic component for EARR. Using a candidate gene approach, we investigated possible linkage of EARR associated with orthodontic treatment with the TNSALP, TNF α , and TNFRSF11...
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Published in | Journal of dental research Vol. 82; no. 5; pp. 356 - 360 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
SAGE Publications
01.05.2003
SAGE PUBLICATIONS, INC |
Subjects | |
Online Access | Get full text |
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Summary: | External apical root resorption (EARR) is a common orthodontic treatment sequela.
Previous studies implicate a substantial genetic component for EARR. Using a
candidate gene approach, we investigated possible linkage of EARR associated with
orthodontic treatment with the TNSALP, TNF
α
, and TNFRSF11A gene
loci. The sample was comprised of 38 American Caucasian families with a total of 79
siblings who completed comprehensive orthodontic treatment. EARR was assessed by
means of pre- and post-treatment radiographs. Buccal swab cells were collected for
extraction and analysis of DNA. No evidence of linkage was found with EARR and the
TNF
α and TNSALP genes.
Non-parametric sibling pair linkage analysis identified evidence of linkage (LOD =
2.5; p = 0.02) of EARR affecting the maxillary central incisor with the
microsatellite marker D18S64 (tightly linked to TNFRSF11A). This indicates that the TNFRSF11A locus, or another tightly linked gene, is associated with
EARR. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-0345 1544-0591 |
DOI: | 10.1177/154405910308200506 |