Untangling the ErbB signalling network
When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion. The network is often dysregulated in cancer and lends credence to the mantra that...
Saved in:
Published in | Nature reviews. Molecular cell biology Vol. 2; no. 2; pp. 127 - 137 |
---|---|
Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Nature Publishing Group
01.02.2001
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion. The network is often dysregulated in cancer and lends credence to the mantra that molecular understanding yields clinical benefit: over 25,000 women with breast cancer have now been treated with trastuzumab (Herceptin), a recombinant antibody designed to block the receptor ErbB2. Likewise, small-molecule enzyme inhibitors and monoclonal antibodies to ErbB1 are in advanced phases of clinical testing. What can this pathway teach us about translating basic science into clinical use? |
---|---|
Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Article-1 ObjectType-Feature-3 ObjectType-Review-2 |
ISSN: | 1471-0072 1471-0080 |
DOI: | 10.1038/35052073 |