Untangling the ErbB signalling network

When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion. The network is often dysregulated in cancer and lends credence to the mantra that...

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Published inNature reviews. Molecular cell biology Vol. 2; no. 2; pp. 127 - 137
Main Authors Yarden, Yosef, Sliwkowski, Mark X
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.02.2001
Subjects
Adhesion
Animals
Cancer
Cell division
Connective tissue
Enzyme inhibitors
Epidermal growth factor
ErbB gene
heregulin
Insects
Kinases
Ligands
Mutation
Neoplasms - genetics
Neoplasms - pathology
Neoplasms - therapy
Receptor, ErbB-2 - metabolism
Signal Transduction
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Summary:When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion. The network is often dysregulated in cancer and lends credence to the mantra that molecular understanding yields clinical benefit: over 25,000 women with breast cancer have now been treated with trastuzumab (Herceptin), a recombinant antibody designed to block the receptor ErbB2. Likewise, small-molecule enzyme inhibitors and monoclonal antibodies to ErbB1 are in advanced phases of clinical testing. What can this pathway teach us about translating basic science into clinical use?
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ISSN:1471-0072
1471-0080
DOI:10.1038/35052073