Physical activity reduces intradermal bacterial load in a murine model submitted to forced swim training - a pilot study

• Published in: Anais da Academia Brasileira de Ciências Vol. 94; no. 2; p. e20200561
• Main Authors: Galantini, Maria P L, Leal, Lorena S, Rodrigues, Karine B, Ribeiro, Israel S, Pereira, Italo S, Gonçalves, Caroline V, Calado, Stéfano P M, Santos, Denisar P Dos, Muniz, Igor P R, Silva, Robson A A DA
• Format: Journal Article
• Language: English
• Published: Brazil Academia Brasileira de Ciências 01.01.2022
• Subjects: infection; mice; MULTIDISCIPLINARY SCIENCES; physical exercise; Staphylococcus aureus; infection; physical exercise; mice; Staphylococcus aureus
• ISSN: 0001-3765; 1678-2690; 1678-2690
• DOI: 10.1590/0001-3765202220200561

Regular exercise is beneficial to health. This study evaluated the effects of moderate and intense physical exercise modalities on intradermal infection by Staphylococcus aureus in a murine model. Mice that practiced moderate exercise had lower bacterial load on lymph nodes and less inflammatory infiltrate in dermis. They presented greater weight, however, less amount of epididymal fat: the weight was increased while they had fat diminished. A positive correlation was observed between lipid content and bacterial load in mice trained at moderate intensity. Animals that were under high intensity exercises presented superior bacterial load on the lymph nodes, increased neutrophil count and circulating lymphocytes, and had leukocyte recruitment to the dermis augmented, when compared to the ones in moderate exercise. These findings suggest that moderate physical activity modulates the immune response in dermal infection caused by S. aureus in a murine model.