Oxaflozane overdose in a child

A case of severe poisoning in a 2 year-old child who ingested 150 mg of oxaflozane, a non-tricyclic antidepressant, is reported. After loss of consciousness, opisthotonos and coma, recovery was obtained with conservative treatment. Atropine-like symptoms were noted. The maximal plasma concentration...

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Bibliographic Details
Published inJournal of toxicology. Clinical toxicology Vol. 30; no. 1; p. 123
Main Authors Dutertre, J P, Barbier, P, Suc, A L, Jonville, A P, Autret, E
Format Journal Article
LanguageEnglish
Published United States 1992
Subjects
Antidepressive Agents - pharmacokinetics
Antidepressive Agents - poisoning
Child, Preschool
Coma - chemically induced
Drug Overdose
Half-Life
Humans
Male
Morpholines - pharmacokinetics
Morpholines - poisoning
Muscle Hypertonia - chemically induced
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Summary:A case of severe poisoning in a 2 year-old child who ingested 150 mg of oxaflozane, a non-tricyclic antidepressant, is reported. After loss of consciousness, opisthotonos and coma, recovery was obtained with conservative treatment. Atropine-like symptoms were noted. The maximal plasma concentration of oxaflozane was 63 ng/mL. The elimination half-life for N-dealkyloxaflozane was 4.8 h.
ISSN:0731-3810
DOI:10.3109/15563659208994452