Exploration of Blood Lipoprotein and Lipid Fraction Profiles in Healthy Subjects through Integrated Univariate, Multivariate, and Network Analysis Reveals Association of Lipase Activity and Cholesterol Esterification with Sex and Age

In this study, we investigated blood lipoprotein and lipid fraction profiles, quantified using nuclear magnetic resonance, in a cohort of 844 healthy blood donors, integrating standard univariate and multivariate analysis with predictive modeling and network analysis. We observed a strong associatio...

Full description

Saved in:
Bibliographic Details
Published inMetabolites Vol. 11; no. 5; p. 326
Main Authors Balder, Yasmijn, Vignoli, Alessia, Tenori, Leonardo, Luchinat, Claudio, Saccenti, Edoardo
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 18.05.2021
MDPI
Subjects
Age
Age groups
analysis of biological networks
Blood & organ donations
Blood donors
Cholesterol
Esterification
Lipase
lipid metabolism
lipidomics
Lipids
Lipoproteins
metabolomics
Multivariate analysis
NMR
Nuclear magnetic resonance
Principal components analysis
Proteins
Sexes
Triglycerides
Variables
Women
Young adults
Online AccessGet full text

Cover

More Information
Summary:In this study, we investigated blood lipoprotein and lipid fraction profiles, quantified using nuclear magnetic resonance, in a cohort of 844 healthy blood donors, integrating standard univariate and multivariate analysis with predictive modeling and network analysis. We observed a strong association of lipoprotein and lipid main fraction profiles with sex and age. Our results suggest an age-dependent remodulation of lipase lipoprotein activity in men and a change in the mechanisms controlling the ratio between esterified and non-esterified cholesterol in both men and women.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo11050326