TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation

Innate lymphoid cells (ILCs) are a recently identified family of heterogeneous immune cells that can be divided into three groups based on their differential developmental requirements and expression of effector cytokines. Among these, group 2 ILCs produce the type 2 cytokines interleukin-5 (IL-5) a...

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Published inScience translational medicine Vol. 5; no. 170; p. 170ra16
Main Authors Kim, Brian S, Siracusa, Mark C, Saenz, Steven A, Noti, Mario, Monticelli, Laurel A, Sonnenberg, Gregory F, Hepworth, Matthew R, Van Voorhees, Abby S, Comeau, Michael R, Artis, David
Format Journal Article
LanguageEnglish
Published United States 30.01.2013
Subjects
Adaptive Immunity
Animals
Cytokines - metabolism
Dermatitis, Atopic - immunology
Dermatitis, Atopic - pathology
Disease Models, Animal
Humans
Immunity, Innate - immunology
Inflammation - immunology
Inflammation - pathology
Interleukin-33
Interleukins - metabolism
Lymphocytes - immunology
Mice
Mice, Inbred C57BL
Protein Binding
Skin - immunology
Skin - pathology
Thymic Stromal Lymphopoietin
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Summary:Innate lymphoid cells (ILCs) are a recently identified family of heterogeneous immune cells that can be divided into three groups based on their differential developmental requirements and expression of effector cytokines. Among these, group 2 ILCs produce the type 2 cytokines interleukin-5 (IL-5) and IL-13 and promote type 2 inflammation in the lung and intestine. However, whether group 2 ILCs reside in the skin and contribute to skin inflammation has not been characterized. We identify a population of skin-resident group 2 ILCs present in healthy human skin that are enriched in lesional human skin from atopic dermatitis (AD) patients. Group 2 ILCs were also found in normal murine skin and were critical for the development of inflammation in a murine model of AD-like disease. Remarkably, in contrast to group 2 ILC responses in the intestine and lung, which are critically regulated by IL-33 and IL-25, group 2 ILC responses in the skin and skin-draining lymph nodes were independent of these canonical cytokines but were critically dependent on thymic stromal lymphopoietin (TSLP). Collectively, these results demonstrate an essential role for IL-33- and IL-25-independent group 2 ILCs in promoting skin inflammation.
ISSN:1946-6242
DOI:10.1126/scitranslmed.3005374