Construct Validation of the Dietary Inflammatory Index (DII) among Young College-Aged Women

The Dietary Inflammatory Index (DII) is designed to assess the inflammatory potential of the diet. While previous research has utilized DII among college-aged women, no study to date has validated it in this population. We conducted a construct validation of DII among 393 healthy women aged 18–31 ye...

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Published inNutrients Vol. 15; no. 21; p. 4553
Main Authors Azarmanesh, Deniz, Pearlman, Jessica, Carbone, Elena T, DiNatale, Janie C, Bertone-Johnson, Elizabeth R
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.10.2023
Subjects
Biomarkers
Chronic illnesses
construct validation
Cytokines
Data collection
Diabetes
Diet
Dietary Inflammatory Index
DII
Disease
Exercise
Fatty acids
Food
Food habits
Health aspects
Immune system
Inflammation
Nutrients
Questionnaires
Tumor necrosis factor
Tumor necrosis factor-TNF
Type 2 diabetes
Vitamins
Women
Womens health
Young adults
young women
United States > US
Massachusetts
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Summary:The Dietary Inflammatory Index (DII) is designed to assess the inflammatory potential of the diet. While previous research has utilized DII among college-aged women, no study to date has validated it in this population. We conducted a construct validation of DII among 393 healthy women aged 18–31 years against a robust panel of 14 inflammatory biomarkers, including CRP, IL-1β, IL-4, IL-6, IL-10, and TNF-α, which were used in the development of DII. Three linear regression models were constructed: (1) an age-adjusted model, (2) the most parsimonious model based on likelihood ratio tests, and (3) a fully adjusted model for age, race, body mass index, waist circumference, physical activity, smoking status, and nonsteroidal anti-inflammatory drug use. DII was derived from the Harvard food frequency questionnaire and categorized into quartiles. Consistent with our hypothesis, DII was negatively and significantly associated with back-transformed IL-10 levels, confirming that a more pro-inflammatory diet was associated with lower levels of an anti-inflammatory cytokine (Model 3: Q4 vs. Q1 β = 0.62; 95% CI: 0.42, 0.93; p-trend = 0.04). While validated in other populations, DII may not be a suitable tool for assessing the inflammatory potential of the diet among college-aged women.
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ISSN:2072-6643
2072-6643
DOI:10.3390/nu15214553