A Repetitive, Steady Mouth Opening Induced an Osteoarthritis-like Lesion in the Rabbit Temporomandibular Joint

Although excessive mechanical stress is assumed to be one of the factors contributing to pathogenesis of temporomandibular joint (TMJ) osteoarthritis (OA), no pure mechanical-stress-induced OA model has been developed without surgical manipulation or puncture of the joint cavity. The purpose of this...

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Published inJournal of dental research Vol. 82; no. 9; pp. 731 - 735
Main Authors Fujisawa, T., Kuboki, T., Kasai, T., Sonoyama, W., Kojima, S., Uehara, J., Komori, C., Yatani, H., Hattori, T., Takigawa, M.
Format Journal Article
LanguageEnglish
Published United States SAGE Publications 01.09.2003
SAGE PUBLICATIONS, INC
Subjects
Animals
Cartilage, Articular - pathology
Cell Division
Chondrocytes - pathology
Dentistry
Disease Models, Animal
Growth Plate - pathology
Male
Mandible - physiopathology
Mandibular Condyle - pathology
Movement
Osteoarthritis - etiology
Osteoarthritis - pathology
Rabbits
Stress, Mechanical
Temporomandibular Joint - pathology
Temporomandibular Joint Disorders - etiology
Temporomandibular Joint Disorders - pathology
Time Factors
articular cartilage
mechanical stress
temporomandibular joint
osteoarthritis
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Summary:Although excessive mechanical stress is assumed to be one of the factors contributing to pathogenesis of temporomandibular joint (TMJ) osteoarthritis (OA), no pure mechanical-stress-induced OA model has been developed without surgical manipulation or puncture of the joint cavity. The purpose of this study was to establish a genuine mechanical-stress-induced OA model of the rabbit TMJ. In the experimental rabbits, repetitive, forced jaw-opening, 3 hrs/day for 5 days, was applied with the use of a general anesthesia protocol. By histological assessment of the TMJ articular tissues, partial eburnation of the articular cartilage, reactive marginal proliferation of the articular cartilage chondrocytes, and nested proliferation of chondrocytes in the subchondral bone area were observed at 7 days after the repetitive, forced-jaw-opening period. These results suggest that the repetitive, forced-jaw-opening protocol without surgical intervention can induce evident OA-like lesions in the rabbit TMJ, and this OA model may greatly contribute to the elucidation of the cartilage degradation mechanism in TMJ OA.
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ISSN:0022-0345
1544-0591
DOI:10.1177/154405910308200914