Ferroptosis as a Novel Therapeutic Target for Diabetes and Its Complications

The global diabetes epidemic and its complications are increasing, thereby posing a major threat to public health. A comprehensive understanding of diabetes mellitus (DM) and its complications is necessary for the development of effective treatments. Ferroptosis is a newly identified form of program...

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Published inFrontiers in endocrinology (Lausanne) Vol. 13; p. 853822
Main Authors Yang, Xi-Ding, Yang, Yong-Yu
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 29.03.2022
Subjects
diabetes
Diabetes Complications - etiology
Diabetes Mellitus - drug therapy
diabetic complications
diabetic kidney disease
Endocrinology
Ferroptosis
Homeostasis
Humans
iron
Reactive Oxygen Species - metabolism
diabetic complications
diabetic kidney disease
iron
ferroptosis
diabetes
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ISSN1664-2392
1664-2392
DOI10.3389/fendo.2022.853822

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Summary:The global diabetes epidemic and its complications are increasing, thereby posing a major threat to public health. A comprehensive understanding of diabetes mellitus (DM) and its complications is necessary for the development of effective treatments. Ferroptosis is a newly identified form of programmed cell death caused by the production of reactive oxygen species and an imbalance in iron homeostasis. Increasing evidence suggests that ferroptosis plays a pivotal role in the pathogenesis of diabetes and diabetes-related complications. In this review, we summarize the potential impact and regulatory mechanisms of ferroptosis on diabetes and its complications, as well as inhibitors of ferroptosis in diabetes and diabetic complications. Therefore, understanding the regulatory mechanisms of ferroptosis and developing drugs or agents that target ferroptosis may provide new treatment strategies for patients with diabetes.
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This article was submitted to Diabetes: Molecular Mechanisms, a section of the journal Frontiers in Endocrinology
Edited by: Ana Stancic, University of Belgrade, Serbia
Reviewed by: Isha Sharma, Northwestern University, United States; Shuangqing Liu, Fourth Medical Center of PLA General Hospital, China; Ping Yao, Huazhong University of Science and Technology, China
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2022.853822