Studies of Isolated Resistance Vessels from Offspring of Essential Hypertensive Patients

In order to investigate whether functional and morphological changes are present in the resistance vasculature before hypertension is established, isolated subcutaneous resistance vessels were studied from 21 young normotensive subjects with a family history of hypertension and 22 controls matched f...

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Published inHypertension (Dallas, Tex. 1979) Vol. 9; no. 6, Part 2 Suppl III; pp. III-155 - III-158
Main Authors AALKLER, CHRISTIAN, HEAGERTY, ANTHONY M, BAILEY, IAN, MULVANY, MICHAEL J, SWALES, JOHN D
Format Journal Article
LanguageEnglish
Published Philadelphia, PA American Heart Association, Inc 01.06.1987
Hagerstown, MD Lippincott
Subjects
Adult
Applied sciences
Blood Vessels - metabolism
Blood Vessels - pathology
Blood Vessels - physiopathology
Calcium - metabolism
Cocaine - pharmacology
Drug Resistance
Exact sciences and technology
Humans
Hypertension - genetics
Hypertension - metabolism
Hypertension - pathology
Hypertension - physiopathology
In Vitro Techniques
Male
Norepinephrine - pharmacology
Other techniques and industries
Vascular Resistance
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Summary:In order to investigate whether functional and morphological changes are present in the resistance vasculature before hypertension is established, isolated subcutaneous resistance vessels were studied from 21 young normotensive subjects with a family history of hypertension and 22 controls matched for age, sex, and weight. The vessels from the offspring of hypertensive patients displayed no morphological changes or differences in reactivity or sensitivity to the vasoconstrictor agonists norepinephrine, angiotensin II, serotonin, and vasopressin. In the presence of cocaine, however, vessels from offspring showed a significantly greater shift in sensitivity to norepinephrine, a phenomenon also observed in previous studies of vessels from hypertensive patients. The results suggest that in essential hypertension, while morphological and functional abnormalities of the resistance vasculature may develop as the blood pressure rises, a defect in neuroeffector activity is present before hypertension is established and may be a manifestation of abnormal sympathetic nervous system activity underlying the disease.
Bibliography:ObjectType-Article-1
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ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.9.6_Pt_2.III155