Evaluation of Quality Change in Salviae Miltiorrhizae Radix et Rhizoma During Drying by LF-NMR and HPLC

• Published in: Analytical Sciences Vol. 38; no. 2; pp. 21P169 - 298
• Main Authors: Liu, Qinrong, Wang, Yishuo, Zhang, Zhenling, Du, Ziwei, Li, Jiazhen, Wu, Yuquan
• Format: Journal Article
• Language: English
• Published: Singapore The Japan Society for Analytical Chemistry 01.02.2022; Springer Singapore
• Subjects: Analytical Chemistry; Chemistry; Chemistry and Materials Science; Original Paper; Low field nuclear magnetic resonance (LF-NMR); High-performance liquid chromatography (HPLC); Danshen
• ISSN: 0910-6340; 1348-2246
• DOI: 10.2116/analsci.21P169

Salviae miltiorrhizae radix et rhizoma (Danshen, in Chinese) is one of the traditional Chinese medicines commonly used in clinical practice. In this study, low field nuclear magnetic resonance (LF-NMR) was used to detect changes in the moisture content during the drying of Danshen . Three water states (bound, immobilized, and free) in Danshen were investigated by multi-exponential fitting of the NMR data. Mass changes during drying were analyzed using high-performance liquid chromatography and partial least squares discriminant analysis. The results revealed that two components, salvianolic acid B and tanshinone, were the main chemical substances that produced the differences. Correlations were found among chemical substances, color, and moisture. LF-NMR can quickly assess the moisture content during drying. It also provides a practical tool for the production and processing of medicines or slices. Graphical abstract