Impact of platelet transfusion on toxicity and mortality after hematopoietic progenitor cell transplantation
Background Thrombocytopenia occurs commonly after hematopoietic progenitor cell transplantation (HPCT) and is associated with potential morbidity and mortality. Few studies have examined the impact of platelet (PLT) transfusion on clinical outcomes in HPCT while optimal PLT transfusion strategies af...
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Published in | Transfusion (Philadelphia, Pa.) Vol. 55; no. 2; pp. 253 - 258 |
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Main Authors | , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Blackwell Publishing Ltd
01.02.2015
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Background
Thrombocytopenia occurs commonly after hematopoietic progenitor cell transplantation (HPCT) and is associated with potential morbidity and mortality. Few studies have examined the impact of platelet (PLT) transfusion on clinical outcomes in HPCT while optimal PLT transfusion strategies after HSCT remain uncertain.
Study Design and Methods
A retrospective single‐center cohort study was conducted on 522 patients undergoing HPCT between January 2002 and December 2007. Associations between PLT transfusion events and clinical characteristics with transplant‐related outcomes were assessed using univariate and multivariate analysis.
Results
Mean number of PLT transfusion events before Day +60 posttransplant was 7.5 (95% confidence interval, 6.7‐8.4) with greater number of events after allogeneic compared with autologous HPCT (p < 0.01). Univariate and multivariate analysis confirmed that the number of PLT transfusion events was associated with increased 100‐day nonrelapse mortality (p < 0.01), posttransplant length of hospital stay (p < 0.01), need for intensive care unit admission (p < 0.01), and number of organs affected by severe toxicity (p < 0.01).
Conclusion
HPCT‐related toxicity and mortality are associated with increased PLT transfusion events. Alternative strategies to reduce PLT transfusions after HPCT may warrant future study. |
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Bibliography: | Canadian Institutes of Health Research (CIHR) istex:CAFD38065492A86236F4AFD60AE4BA760940D8D5 Ottawa Hospital Foundation ark:/67375/WNG-QG46QP8G-G ASH Scholar Award ArticleID:TRF12817 |
ISSN: | 0041-1132 1537-2995 |
DOI: | 10.1111/trf.12817 |