Examination of national lymph node evaluation practices for adult extremity soft tissue sarcoma

• Published in: Journal of surgical oncology Vol. 110; no. 6; pp. 682 - 688
• Main Authors: Sherman, Karen L., Kinnier, Christine V., Farina, Domenico A., Wayne, Jeffrey D., Laskin, William B., Agulnik, Mark, Attar, Samer, Hayes, John P., Peabody, Terrance, Bilimoria, Karl Y.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.11.2014; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Databases, Factual; Extremities; Female; Humans; lymph node excision; Lymph Nodes - pathology; Lymphatic Metastasis; Male; Middle Aged; Multivariate Analysis; Neoplasm Grading; neoplasms; Practice Patterns, Physicians' - statistics & numerical data; retrospective studies; Sarcoma - secondary; Soft Tissue Neoplasms - pathology; United States; United States; retrospective studies; lymph node excision; neoplasms; lymphatic metastasis
• ISSN: 0022-4790; 1096-9098
• DOI: 10.1002/jso.23687

Background and Objectives Lymph node evaluation recommendations for extremity soft tissue sarcoma (ESTS) are absent from national guidelines. Our objectives were (1) to assess rates and predictors of nodal evaluation, and (2) to assess rates and predictors of nodal metastases. Methods ESTS patients from the National Cancer Data Base (2000–2009) were assessed, and regression models were used to identify factors associated with nodal evaluation and metastases. Results Of 27,536 ESTS patients, 1,924 (7%) underwent nodal evaluation, and of these, 290 (15%) had nodal metastases. Nodal evaluation was most frequently performed for rhabdomyosarcoma (15.6%), angiosarcoma (10.0%), clear cell sarcoma (39.3%), epithelioid sarcoma (28.1%), and synovial sarcoma (9.3%). On multivariable analysis, factors associated with nodal evaluation included histologic subtype, tumor size, and grade. Nodal metastasis rates were highest among patients with rhabdomyosarcoma (32.1%), angiosarcoma (24.1%), clear cell sarcoma (27.7%), and epithelioid sarcoma (31.8%). On multivariable analysis, factors associated with nodal metastases included histologic subtype, tumor size, and grade. Conclusions Nodal evaluation rates are highest among certain expected subtypes but are generally low. However, nodal metastasis rates for many histologic subtypes in patients selected for lymph node evaluation may be higher than previously reported. Multi‐institutional studies should address nodal evaluation for ESTS. J. Surg. Oncol. 2014 110:682–688. © 2014 Wiley Periodicals, Inc.