Inclusion of pethidine in lidocaine for infiltration improves analgesia following tonsillectomy in children
Background:Previous work has demonstrated that pethidine exerts local anaesthetic effects on peripheral nerves in vivo. We examined the effects of infiltration anaesthesia by a combination of pethidine and lidocaine on post‐tonsillectomy pain and restlessness in children. Methods:Eighty children wer...
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Published in | Acta anaesthesiologica Scandinavica Vol. 41; no. 2; pp. 214 - 217 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Oxford, UK
Blackwell Publishing Ltd
01.02.1997
Blackwell |
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Abstract | Background:Previous work has demonstrated that pethidine exerts local anaesthetic effects on peripheral nerves in vivo. We examined the effects of infiltration anaesthesia by a combination of pethidine and lidocaine on post‐tonsillectomy pain and restlessness in children.
Methods:Eighty children were randomly allocated to receive peritonsillar infiltration postoperatively with 3 ml of lidocaine 2% (1.5 ml on each side) combined with either 0.1 ml pethidine, 10 mg · ml‐1, (pethidine group) or 0.1 ml normal saline (control group). Pain and behaviour were assessed at 1, 3, 6 and 12 h postoperatively and on the following morning by the patients and by a nurse blinded to previous treatment.
Results: Patients in the pethidine group had lower pain scores than those in the control group at rest as well as swallowing during the whole observation period (P < 0.05). Paracetamol was given to 34/40 children in the control group and to 6/40 children in the pethidine group. The corresponding figures for pethidine administration were 6/40 and 0/40, respectively. Patients in the pethidine group displayed a more rapid return to calm wakefulness than those in the control group (P <0.01).
Conclusions: Inclusion of a low dose of pethidine in lidocaine for tonsillar infiltration improves pain relief after tonsillectomy in children. |
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AbstractList | Background:Previous work has demonstrated that pethidine exerts local anaesthetic effects on peripheral nerves in vivo. We examined the effects of infiltration anaesthesia by a combination of pethidine and lidocaine on post‐tonsillectomy pain and restlessness in children.
Methods:Eighty children were randomly allocated to receive peritonsillar infiltration postoperatively with 3 ml of lidocaine 2% (1.5 ml on each side) combined with either 0.1 ml pethidine, 10 mg · ml‐1, (pethidine group) or 0.1 ml normal saline (control group). Pain and behaviour were assessed at 1, 3, 6 and 12 h postoperatively and on the following morning by the patients and by a nurse blinded to previous treatment.
Results: Patients in the pethidine group had lower pain scores than those in the control group at rest as well as swallowing during the whole observation period (P < 0.05). Paracetamol was given to 34/40 children in the control group and to 6/40 children in the pethidine group. The corresponding figures for pethidine administration were 6/40 and 0/40, respectively. Patients in the pethidine group displayed a more rapid return to calm wakefulness than those in the control group (P <0.01).
Conclusions: Inclusion of a low dose of pethidine in lidocaine for tonsillar infiltration improves pain relief after tonsillectomy in children. Background: Previous work has demonstrated that pethidine exerts local anaesthetic effects on peripheral nerves in vivo. We examined the effects of infiltration anaesthesia by a combination of pethidine and lidocaine on post‐tonsillectomy pain and restlessness in children. Methods: Eighty children were randomly allocated to receive peritonsillar infiltration postoperatively with 3 ml of lidocaine 2% (1.5 ml on each side) combined with either 0.1 ml pethidine, 10 mg · ml ‐1 , (pethidine group) or 0.1 ml normal saline (control group). Pain and behaviour were assessed at 1, 3, 6 and 12 h postoperatively and on the following morning by the patients and by a nurse blinded to previous treatment. Results: Patients in the pethidine group had lower pain scores than those in the control group at rest as well as swallowing during the whole observation period ( P < 0.05). Paracetamol was given to 34/40 children in the control group and to 6/40 children in the pethidine group. The corresponding figures for pethidine administration were 6/40 and 0/40, respectively. Patients in the pethidine group displayed a more rapid return to calm wakefulness than those in the control group ( P <0.01). Conclusions: Inclusion of a low dose of pethidine in lidocaine for tonsillar infiltration improves pain relief after tonsillectomy in children. Previous work has demonstrated that pethidine exerts local anaesthetic effects on peripheral nerves in vivo. We examined the effects of infiltration anaesthesia by a combination of pethidine and lidocaine on post-tonsillectomy pain and restlessness in children. Eighty children were randomly allocated to receive peritonsillar infiltration postoperatively with 3 ml of lidocaine 2% (1.5 ml on each side) combined with either 0.1 ml pethidine, 10 mg.ml-1, (pethidine group) or 0.1 ml normal saline (control group). Pain and behaviour were assessed at 1, 3, 6 and 12 h postoperatively and on the following morning by the patients and by a nurse blinded to previous treatment. Patients in the pethidine group had lower pain scores than those in the control group at rest as well as swallowing during the whole observation period (P < 0.05). Paracetamol was given to 34/40 children in the control group and to 6/40 children in the pethidine group. The corresponding figures for pethidine administration were 6/40 and 0/40, respectively. Patients in the pethidine group displayed a more rapid return to calm wakefulness than those in the control group (P < 0.01). Inclusion of a low dose of pethidine in lidocaine for tonsillar infiltration improves pain relief after tonsillectomy in children. |
Author | ELHAKIM, M. SALAM, A. Y. ABDUL EID, A. KASCHEF, N. MOSTAFA, B. E. |
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Keywords | Human Postoperative Pethidine Opiates Narcotic analgesic Local anesthetic Analgesia Regional anesthesia Pain Tonsillectomy Surgery ENT disease Infiltration Lidocaine Child |
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Evidence for involvement of mu, delta and kappa receptors publication-title: J Pharmacol Exp Ther contributor: fullname: Stein C – ident: e_1_2_1_8_2 doi: 10.1038/clpt.1987.123 – ident: e_1_2_1_5_2 doi: 10.1111/j.1365-2044.1992.tb02338.x – volume: 72 start-page: 119 year: 1994 ident: e_1_2_1_19_2 article-title: Analgesia of two doses of intra–articular morphine in day–case arthros–copy publication-title: Br J Anaesth contributor: fullname: Juelsgaard P – ident: e_1_2_1_9_2 doi: 10.1016/0304-3959(76)90113-5 – ident: e_1_2_1_3_2 doi: 10.1111/j.1365-2044.1986.tb12872.x – volume: 16 start-page: 204 year: 1991 ident: e_1_2_1_6_2 article-title: The effect of fentanyl, meperidine, and diamorphine on nerve conduction in vitro publication-title: Reg Anesth contributor: fullname: Power I – ident: e_1_2_1_11_2 doi: 10.1016/S0140-6736(74)90884-8 – ident: e_1_2_1_16_2 doi: 10.1016/0304-3940(88)90412-0 – ident: e_1_2_1_12_2 doi: 10.1111/j.1399-6576.1987.tb02655.x |
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Snippet | Background:Previous work has demonstrated that pethidine exerts local anaesthetic effects on peripheral nerves in vivo. We examined the effects of infiltration... Previous work has demonstrated that pethidine exerts local anaesthetic effects on peripheral nerves in vivo. We examined the effects of infiltration... Background: Previous work has demonstrated that pethidine exerts local anaesthetic effects on peripheral nerves in vivo. We examined the effects of... |
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SubjectTerms | Analgesics Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Anesthesia, Local anesthetics Anesthetics, Local - administration & dosage Anesthetics, Local - adverse effects Biological and medical sciences Child Child, Preschool children Double-Blind Method Humans Lidocaine - administration & dosage Lidocaine - adverse effects local: lidocaine Medical sciences Meperidine - administration & dosage Meperidine - adverse effects Neuropharmacology opioid opioid: pethidine Pain Measurement Pain, Postoperative - drug therapy Pain, Postoperative - prevention & control pain: postoperative pediatric peripheral Pharmacology. Drug treatments Premedication receptor surgery Tonsillectomy |
Title | Inclusion of pethidine in lidocaine for infiltration improves analgesia following tonsillectomy in children |
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