Patterns and treatment of neck metastases in patients with salivary gland cancers
Background Management of the neck in patients with salivary gland cancer is controversial. This study aimed to identify clinicopathologic characteristics associated with regional metastases and regional recurrence in patients with salivary gland carcinoma. Methods Of 363 study patients, 51 underwent...
Saved in:
Published in | Journal of surgical oncology Vol. 111; no. 8; pp. 1000 - 1006 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Blackwell Publishing Ltd
01.06.2015
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Background
Management of the neck in patients with salivary gland cancer is controversial. This study aimed to identify clinicopathologic characteristics associated with regional metastases and regional recurrence in patients with salivary gland carcinoma.
Methods
Of 363 study patients, 51 underwent therapeutic neck dissection (TND) and 312 underwent either elective neck dissection (END, n = 110) or no neck dissection (NoND, n = 202). Univariate and multivariate analyses were performed to identify clinicopathologic characteristics associated with regional metastases and recurrence.
Results
Pathologic neck metastases were identified in 17/110 (15.5%) END patients and neck recurrence was identified in 5/202 (2.5%) NoND patients. Histologic grade (P < 0.001), tumor site (P = 0.008), and lymphovascular invasion (P < 0.001) were independent risk factors for neck metastases. Nodal metastases were more common in high‐grade tumors (P < 0.001), at levels I–III in END patients and levels I–V in TND patients. Multivariate analyses identified histologic grade (P = 0.020), clinical N2 classification (P = 0.007), and extranodal extension (P = 0.005) as independent factors for regional recurrence after treatment.
Conclusions
Patients with high‐grade cancers should receive END involving levels I–III, whereas patients with node‐positive salivary cancers should receive comprehensive TND involving all levels (I–V). J. Surg. Oncol. 2015 111:1000–1006. © 2015 Wiley Periodicals, Inc. |
---|---|
Bibliography: | National Research Foundation of Ministry of Education, Science and Technology - No. NRF-2012R1A1A2002039 ArticleID:JSO23914 istex:66E240687FBC7B543FBACC1D6D89C2A69D35AE5E Asan Instititute for Life Science - No. 2014-0306 ark:/67375/WNG-HRNJ7Q8B-2 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-4790 1096-9098 |
DOI: | 10.1002/jso.23914 |