Transcription termination and anti‐termination in E. coli

Transcription termination in Escherichia coli is controlled by many factors. The sequence of the DNA template, the structure of the transcript, and the actions of auxiliary proteins all play a role in determining the efficiency of the process. Termination is regulated and can be enhanced or suppress...

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Bibliographic Details
Published inGenes to cells : devoted to molecular & cellular mechanisms Vol. 7; no. 8; pp. 755 - 768
Main Authors Nudler, Evgeny, Gottesman, Max E.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.08.2002
Subjects
Bacteriophages - genetics
Escherichia coli - genetics
Terminator Regions, Genetic
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Summary:Transcription termination in Escherichia coli is controlled by many factors. The sequence of the DNA template, the structure of the transcript, and the actions of auxiliary proteins all play a role in determining the efficiency of the process. Termination is regulated and can be enhanced or suppressed by host and phage proteins. This complex reaction is rapidly yielding to biochemical and structural analysis of the interacting factors. Below we review and attempt to unify into basic principles the remarkable recent progress in understanding transcription termination and anti‐termination.
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ISSN:1356-9597
1365-2443
DOI:10.1046/j.1365-2443.2002.00563.x