Clinical significance of serum apolipoproteins as a predictor of coronary heart disease risk in Korean men

• Published in: Clinical endocrinology (Oxford) Vol. 84; no. 1; pp. 63 - 71
• Main Authors: Ryoo, Jae-Hong, Park, Sung Keun, Hong, Hyun Pyo, Kim, Min-Gi, Ha, Chul Soo
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.01.2016; Wiley Subscription Services, Inc
• Subjects: Adult; Apolipoprotein A-I - blood; Apolipoproteins; Apolipoproteins B - blood; Asian Continental Ancestry Group; Cardiovascular disease; Cholesterol; Coronary Disease - blood; Coronary Disease - diagnosis; Coronary Disease - ethnology; Follow-Up Studies; Health risk assessment; Humans; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Republic of Korea; Risk Assessment - methods; Risk Assessment - statistics & numerical data; Risk Factors
• ISSN: 0300-0664; 1365-2265
• DOI: 10.1111/cen.12843

Summary Objective Although serum apolipoprotein measurement is known to be associated with coronary heart disease (CHD) risk, there is only limited information about the clinical significance of lipid profiles such as ApoA, ApoB and A/B ratio in predicting CHD risk in Asians. Therefore, this cohort study was conducted to evaluate the longitudinal effects of baseline serum apolipoprotein measurements on CHD risk in Korean men. Design Initially, an intermediate and high Framingham risk score (FRS)‐free cohort of 23 918 healthy Korean men was followed until 2010. FRS was calculated for each man and divided into three levels of risk <10% (low), 10–19% (intermediate) and ≥20% (high). More‐than‐a‐moderate CHD risk group (participants with FRS ≥ 10%) and high CHD risk group (participants with FRS ≥ 20%) were defined as our two dependent variables. Cox proportional hazards models were performed. Results In the more‐than‐a‐moderate CHD risk group, the total and average follow‐up periods were 83340·2 and 3·48 person‐years, respectively, and 3763 (15·7%) incident cases developed between 2006 and 2010. In the high CHD risk group, the total and average follow‐up periods were 87868·8 and 3·67 person‐years, respectively, and 344 (1·4%) incident cases developed between 2006 and 2010. Multivariate‐adjusted analyses showed a strong statistically significant relationship between the quintile groups of apolipoprotein B (ApoB), apolipoprotein A‐1 (ApoA‐1) and apolipoprotein B/apolipoprotein A‐1 (ApoB/A‐1) ratio and both the more‐than‐a‐moderate CHD risk and high CHD risk. Conclusions Serum ApoB, ApoA‐1 and ApoB/A‐1 ratio levels are independently associated with CHD risk in Korean men.