MR detection of cytoplasmic fat in clear cell renal cell carcinoma utilizing chemical shift gradient-echo imaging

• Published in: Journal of magnetic resonance imaging Vol. 9; no. 4; pp. 579 - 585
• Main Authors: Yoshimitsu, Kengo, Honda, Hiroshi, Kuroiwa, Toshiro, Irie, Hiroyuki, Tajima, Tsuyoshi, Jimi, Makiko, Kuroiwa, Kentaro, Naito, Seiji, Masuda, Kouji
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.04.1999
• Subjects: Adenocarcinoma, Clear Cell - diagnosis; Aged; Carcinoma, Renal Cell - diagnosis; Cytoplasm - pathology; Diagnosis, Differential; diagnosis: kidney neoplasm; Female; Humans; Kidney - pathology; kidney neoplasm; Kidney Neoplasms - diagnosis; Magnetic Resonance Spectroscopy - instrumentation; Magnetic Resonance Spectroscopy - methods; Male; Middle Aged; MR: Fat detection; MR: Fat detection, MRI; MRI; Retrospective Studies; Statistics, Nonparametric
• ISSN: 1053-1807; 1522-2586
• DOI: 10.1002/(SICI)1522-2586(199904)9:4<579::AID-JMRI12>3.0.CO;2-S

We attempted to determine whether cytoplasmic fat in clear cell renal cell carcinoma (RCC) can be identified by chemical shift gradient‐echo magnetic resonance imaging (CSI). CSI was performed for 22 clear cell RCCs and 30 other renal tumors (including 16 non‐clear cell RCCs), all of which were surgically proven. Signal reduction in out‐of‐phase images of these tumors was retrospectively evaluated and compared. The signal loss ratio (SLR) was defined and calculated. Fat staining of specimens from 16 tumors was performed and correlated with SLR. SLR was significantly higher in clear cell RCCs than in non‐clear cell RCCs (P < 0.001). There was a significant correlation between degree of fat staining positivity of the specimens and SLR (P < 0.01). When signal reduction in out‐of‐phase images suggested the diagnosis of clear cell RCC, correct diagnosis of this entity was made in resected renal tumors with sensitivity, specificity, and accuracy of 82%, 90%, and 87%, respectively. CSI can demonstrate cytoplasmic fat in clear cell RCCs, which helps to differentiate this entity from other RCCs.J. Magn. Reson. Imaging 1999;9:579–585. © 1999 Wiley‐Liss, Inc.