Contact angles and wetting of pharmaceutical powders

Contact angles of pharmaceutical powders were determined by the h-epsilon method, which consists essentially of measuring the maximum height of a drop of liquid fomed on a presaturated compact of the material. Determinations with aspirin as the test material indicate that the measured value is indep...

Full description

Saved in:
Bibliographic Details
Published inJournal of pharmaceutical sciences Vol. 65; no. 6; p. 843
Main Authors Lerk, C F, Schoonen, A J, Fell, J T
Format Journal Article
LanguageEnglish
Published United States 01.06.1976
Subjects
Aspirin
Particle Size
Powders
Surface Properties
Time Factors
Online AccessGet more information

Cover

More Information
Summary:Contact angles of pharmaceutical powders were determined by the h-epsilon method, which consists essentially of measuring the maximum height of a drop of liquid fomed on a presaturated compact of the material. Determinations with aspirin as the test material indicate that the measured value is independent of the particle size of the powder and the porosity of the cake. The method was extended to include determinations on mixed powder systems. The results show that the hydrophobic material dominates with large particle-size powders; with small particle sizes, a linear relationship between the cosine of the contact angle of the mixed system and the proportion of the components is obtained. Results are presented for a wide variety of materials of pharmaceutical interest.
ISSN:0022-3549
DOI:10.1002/jps.2600650611