The Focal Adhesion Analysis Server: a web tool for analyzing focal adhesion dynamics

The Focal Adhesion Analysis Server (FAAS) is a web-based implementation of a set of computer vision algorithms designed to quantify the behavior of focal adhesions in cells imaged in 2D cultures. The input consists of one or more images of a labeled focal adhesion protein. The outputs of the system...

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Bibliographic Details
Published inF1000 research Vol. 2; p. 68
Main Authors Berginski, Matthew E, Gomez, Shawn M
Format Journal Article
LanguageEnglish
Published England F1000Research 04.03.2013
F1000 Research Ltd
Subjects
Cell Adhesion
Web Tools
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Summary:The Focal Adhesion Analysis Server (FAAS) is a web-based implementation of a set of computer vision algorithms designed to quantify the behavior of focal adhesions in cells imaged in 2D cultures. The input consists of one or more images of a labeled focal adhesion protein. The outputs of the system include a range of static and dynamic measurements for the adhesions present in each image as well as how these properties change over time. The user is able to adjust several parameters important for proper focal adhesion identification. This system provides a straightforward tool for the global, unbiased assessment of focal adhesion behavior common in optical microscopy studies. The webserver is available at: http://faas.bme.unc.edu/.
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MEB and SMG conceived the study, MEB coded the web application, MEB and SMG wrote the manuscript. All authors read and approved the manuscript.
Competing interests: No competing interests were disclosed.
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.2-68.v1