Bioconversion of Cardiac Aglycones by Gibberella saubinettii (MONT.) SACC

Bioconversions of several cardiac aglycones by a strain of Gibberella saubinettii (MONT.) SACC. were repoted. Digitoxigenin was converted to digoxigenin in a good yield. Digitoxigenone was transformed into 3-dehydrodigoxigenin, 3-epidigitoxigenin, and 3-epidigoxigenin. Diginatigenin was obtained in...

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Published inChemical & pharmaceutical bulletin Vol. 8; no. 6; pp. 530 - 534
Main Authors Okada, Masashi, Yamada, Atsushi, Ishidate, Morizo
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 1960
Japan Science and Technology Agency
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Summary:Bioconversions of several cardiac aglycones by a strain of Gibberella saubinettii (MONT.) SACC. were repoted. Digitoxigenin was converted to digoxigenin in a good yield. Digitoxigenone was transformed into 3-dehydrodigoxigenin, 3-epidigitoxigenin, and 3-epidigoxigenin. Diginatigenin was obtained in approximately 6% yield from gitoxigenin. Oleandrigenin gave 16-monoacetyldiginatigenin (ca. 15% yield) and diginatigenin (ca. 2%yield), but the formation of gitoxigenin from oleandrigenin by incubation was found to be quite small. Enzymatic hydrolysis of 16β-acetoxyl group of the cardenolide was discussed.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.8.530