Bioconversion of Cardiac Aglycones by Gibberella saubinettii (MONT.) SACC
Bioconversions of several cardiac aglycones by a strain of Gibberella saubinettii (MONT.) SACC. were repoted. Digitoxigenin was converted to digoxigenin in a good yield. Digitoxigenone was transformed into 3-dehydrodigoxigenin, 3-epidigitoxigenin, and 3-epidigoxigenin. Diginatigenin was obtained in...
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Published in | Chemical & pharmaceutical bulletin Vol. 8; no. 6; pp. 530 - 534 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Tokyo
The Pharmaceutical Society of Japan
1960
Japan Science and Technology Agency |
Online Access | Get full text |
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Summary: | Bioconversions of several cardiac aglycones by a strain of Gibberella saubinettii (MONT.) SACC. were repoted. Digitoxigenin was converted to digoxigenin in a good yield. Digitoxigenone was transformed into 3-dehydrodigoxigenin, 3-epidigitoxigenin, and 3-epidigoxigenin. Diginatigenin was obtained in approximately 6% yield from gitoxigenin. Oleandrigenin gave 16-monoacetyldiginatigenin (ca. 15% yield) and diginatigenin (ca. 2%yield), but the formation of gitoxigenin from oleandrigenin by incubation was found to be quite small. Enzymatic hydrolysis of 16β-acetoxyl group of the cardenolide was discussed. |
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ISSN: | 0009-2363 1347-5223 |
DOI: | 10.1248/cpb.8.530 |