R-wave amplitude response to myocardial ischemia in hypertrophic cardiomyopathy

Abstract Background and Purpose R-wave amplitude change during exercise has been reported to enhance diagnostic value for myocardial ischemia in coronary heart disease. Methods We summed up R-wave amplitude in all the 12 leads during exercise testing and correlated the results with regional myocardi...

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Published in	Journal of electrocardiology Vol. 41; no. 1; pp. 68 - 71
Main Authors	Kawasaki, Tatsuya, MD, PhD, Akakabe, Yoshiki, MD, Yamano, Michiyo, MD, Miki, Shigeyuki, MD, PhD, Kamitani, Tadaaki, MD, PhD, Kuribayashi, Toshiro, MD, PhD, Sugihara, Hiroki, MD, PhD
Format	Journal Article
Language	English
Published	United States Elsevier Inc 2008 Elsevier Science Ltd
Subjects	Adult Aged Cardiomyopathy, Hypertrophic - complications Cardiomyopathy, Hypertrophic - diagnosis Cardiovascular Diagnosis, Computer-Assisted - methods Electrocardiography Electrocardiography - methods Exercise Test Female Humans Hypertrophic cardiomyopathy Male Middle Aged Myocardial ischemia Myocardial Ischemia - complications Myocardial Ischemia - diagnosis R-wave Reproducibility of Results Sensitivity and Specificity Hypertrophic cardiomyopathy Electrocardiography Myocardial ischemia R-wave
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Abstract	Abstract Background and Purpose R-wave amplitude change during exercise has been reported to enhance diagnostic value for myocardial ischemia in coronary heart disease. Methods We summed up R-wave amplitude in all the 12 leads during exercise testing and correlated the results with regional myocardial ischemia or diffuse subendocardial ischemia as detected by scintigraphy in 49 patients with hypertrophic cardiomyopathy (HCM) and 16 controls. Results The sum of R-wave amplitude decreased during exercise in patients with HCM (mean, 12.4 mV to 11.7 mV, P < .01) as well as in controls (8.0 mV to 7.7 mV, P < .05). Percent changes in the sum of R-wave amplitude did not differ between 4 subgroups of patients with HCM: one having both regional and subendocardial ischemia, one only the former, one only the latter, and one neither of them (mean, 6.5%, 7.7%, 4.6%, and 5.1%; P = .79). Conclusions R-wave amplitude response to exercise failed to demonstrate myocardial ischemia in our patients with HCM.
AbstractList	R-wave amplitude change during exercise has been reported to enhance diagnostic value for myocardial ischemia in coronary heart disease. We summed up R-wave amplitude in all the 12 leads during exercise testing and correlated the results with regional myocardial ischemia or diffuse subendocardial ischemia as detected by scintigraphy in 49 patients with hypertrophic cardiomyopathy (HCM) and 16 controls. The sum of R-wave amplitude decreased during exercise in patients with HCM (mean, 12.4 mV to 11.7 mV, P < .01) as well as in controls (8.0 mV to 7.7 mV, P < .05). Percent changes in the sum of R-wave amplitude did not differ between 4 subgroups of patients with HCM: one having both regional and subendocardial ischemia, one only the former, one only the latter, and one neither of them (mean, 6.5%, 7.7%, 4.6%, and 5.1%; P = .79). R-wave amplitude response to exercise failed to demonstrate myocardial ischemia in our patients with HCM. BACKGROUND AND PURPOSER-wave amplitude change during exercise has been reported to enhance diagnostic value for myocardial ischemia in coronary heart disease.METHODSWe summed up R-wave amplitude in all the 12 leads during exercise testing and correlated the results with regional myocardial ischemia or diffuse subendocardial ischemia as detected by scintigraphy in 49 patients with hypertrophic cardiomyopathy (HCM) and 16 controls.RESULTSThe sum of R-wave amplitude decreased during exercise in patients with HCM (mean, 12.4 mV to 11.7 mV, P < .01) as well as in controls (8.0 mV to 7.7 mV, P < .05). Percent changes in the sum of R-wave amplitude did not differ between 4 subgroups of patients with HCM: one having both regional and subendocardial ischemia, one only the former, one only the latter, and one neither of them (mean, 6.5%, 7.7%, 4.6%, and 5.1%; P = .79).CONCLUSIONSR-wave amplitude response to exercise failed to demonstrate myocardial ischemia in our patients with HCM. Abstract Background and Purpose R-wave amplitude change during exercise has been reported to enhance diagnostic value for myocardial ischemia in coronary heart disease. Methods We summed up R-wave amplitude in all the 12 leads during exercise testing and correlated the results with regional myocardial ischemia or diffuse subendocardial ischemia as detected by scintigraphy in 49 patients with hypertrophic cardiomyopathy (HCM) and 16 controls. Results The sum of R-wave amplitude decreased during exercise in patients with HCM (mean, 12.4 mV to 11.7 mV, P < .01) as well as in controls (8.0 mV to 7.7 mV, P < .05). Percent changes in the sum of R-wave amplitude did not differ between 4 subgroups of patients with HCM: one having both regional and subendocardial ischemia, one only the former, one only the latter, and one neither of them (mean, 6.5%, 7.7%, 4.6%, and 5.1%; P = .79). Conclusions R-wave amplitude response to exercise failed to demonstrate myocardial ischemia in our patients with HCM. BACKGROUND AND PURPOSE: R-wave amplitude change during exercise has been reported to enhance diagnostic value for myocardial ischemia in coronary heart disease. METHODS: We summed up R-wave amplitude in all the 12 leads during exercise testing and correlated the results with regional myocardial ischemia or diffuse subendocardial ischemia as detected by scintigraphy in 49 patients with hypertrophic cardiomyopathy (HCM) and 16 controls. RESULTS: The sum of R-wave amplitude decreased during exercise in patients with HCM (mean, 12.4 mV to 11.7 mV, P < .01) as well as in controls (8.0 mV to 7.7 mV, P < .05). Percent changes in the sum of R-wave amplitude did not differ between 4 subgroups of patients with HCM: one having both regional and subendocardial ischemia, one only the former, one only the latter, and one neither of them (mean, 6.5%, 7.7%, 4.6%, and 5.1%; P = .79). CONCLUSIONS: R-wave amplitude response to exercise failed to demonstrate myocardial ischemia in our patients with HCM. R-wave amplitude change during exercise has been reported to enhance diagnostic value for myocardial ischemia in coronary heart disease. We summed up R-wave amplitude in all the 12 leads during exercise testing and correlated the results with regional myocardial ischemia or diffuse subendocardial ischemia as detected by scintigraphy in 49 patients with hypertrophic cardiomyopathy (HCM) and 16 controls. The sum of R-wave amplitude decreased during exercise in patients with HCM (mean, 12.4 mV to 11.7 mV, P < .01) as well as in controls (8.0 mV to 7.7 mV, P < .05). Percent changes in the sum of R-wave amplitude did not differ between 4 subgroups of patients with HCM: one having both regional and subendocardial ischemia, one only the former, one only the latter, and one neither of them (mean, 6.5%, 7.7%, 4.6%, and 5.1%; P = .79). R-wave amplitude response to exercise failed to demonstrate myocardial ischemia in our patients with HCM.
Author	Yamano, Michiyo, MD Miki, Shigeyuki, MD, PhD Akakabe, Yoshiki, MD Kamitani, Tadaaki, MD, PhD Sugihara, Hiroki, MD, PhD Kawasaki, Tatsuya, MD, PhD Kuribayashi, Toshiro, MD, PhD
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Snippet	Abstract Background and Purpose R-wave amplitude change during exercise has been reported to enhance diagnostic value for myocardial ischemia in coronary heart... R-wave amplitude change during exercise has been reported to enhance diagnostic value for myocardial ischemia in coronary heart disease. We summed up R-wave... BACKGROUND AND PURPOSE: R-wave amplitude change during exercise has been reported to enhance diagnostic value for myocardial ischemia in coronary heart... BACKGROUND AND PURPOSER-wave amplitude change during exercise has been reported to enhance diagnostic value for myocardial ischemia in coronary heart...
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SubjectTerms	Adult Aged Cardiomyopathy, Hypertrophic - complications Cardiomyopathy, Hypertrophic - diagnosis Cardiovascular Diagnosis, Computer-Assisted - methods Electrocardiography Electrocardiography - methods Exercise Test Female Humans Hypertrophic cardiomyopathy Male Middle Aged Myocardial ischemia Myocardial Ischemia - complications Myocardial Ischemia - diagnosis R-wave Reproducibility of Results Sensitivity and Specificity
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Title	R-wave amplitude response to myocardial ischemia in hypertrophic cardiomyopathy
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