R-wave amplitude response to myocardial ischemia in hypertrophic cardiomyopathy

Abstract Background and Purpose R-wave amplitude change during exercise has been reported to enhance diagnostic value for myocardial ischemia in coronary heart disease. Methods We summed up R-wave amplitude in all the 12 leads during exercise testing and correlated the results with regional myocardi...

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Published inJournal of electrocardiology Vol. 41; no. 1; pp. 68 - 71
Main Authors Kawasaki, Tatsuya, MD, PhD, Akakabe, Yoshiki, MD, Yamano, Michiyo, MD, Miki, Shigeyuki, MD, PhD, Kamitani, Tadaaki, MD, PhD, Kuribayashi, Toshiro, MD, PhD, Sugihara, Hiroki, MD, PhD
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 2008
Elsevier Science Ltd
Subjects
Adult
Aged
Cardiomyopathy, Hypertrophic - complications
Cardiomyopathy, Hypertrophic - diagnosis
Cardiovascular
Diagnosis, Computer-Assisted - methods
Electrocardiography
Electrocardiography - methods
Exercise Test
Female
Humans
Hypertrophic cardiomyopathy
Male
Middle Aged
Myocardial ischemia
Myocardial Ischemia - complications
Myocardial Ischemia - diagnosis
R-wave
Reproducibility of Results
Sensitivity and Specificity
Hypertrophic cardiomyopathy
Electrocardiography
Myocardial ischemia
R-wave
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Summary:Abstract Background and Purpose R-wave amplitude change during exercise has been reported to enhance diagnostic value for myocardial ischemia in coronary heart disease. Methods We summed up R-wave amplitude in all the 12 leads during exercise testing and correlated the results with regional myocardial ischemia or diffuse subendocardial ischemia as detected by scintigraphy in 49 patients with hypertrophic cardiomyopathy (HCM) and 16 controls. Results The sum of R-wave amplitude decreased during exercise in patients with HCM (mean, 12.4 mV to 11.7 mV, P < .01) as well as in controls (8.0 mV to 7.7 mV, P < .05). Percent changes in the sum of R-wave amplitude did not differ between 4 subgroups of patients with HCM: one having both regional and subendocardial ischemia, one only the former, one only the latter, and one neither of them (mean, 6.5%, 7.7%, 4.6%, and 5.1%; P = .79). Conclusions R-wave amplitude response to exercise failed to demonstrate myocardial ischemia in our patients with HCM.
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ISSN:0022-0736
1532-8430
DOI:10.1016/j.jelectrocard.2007.07.008