Altered expression of imprinted genes in patients with cytogenetically normal‑acute myeloid leukemia: Implications for leukemogenesis and survival outcomes

• Published in: Molecular and clinical oncology Vol. 19; no. 6
• Main Authors: Yang, Ming-Yu, Hsu, Cheng-Ming, Lin, Pai-Mei, Yang, Chao-Hui, Hu, Ming-Luen, Chen, I-Ya, Lin, Sheng-Fung
• Format: Journal Article
• Language: English
• Published: Athens Spandidos Publications 01.12.2023; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Antisense RNA; Archives & records; Blood cancer; Cancer; DNA binding proteins; Epigenetic inheritance; Epigenetics; Gene expression; Genes; Genetic aspects; Hospitals; Leukemia; Medical prognosis; Oncology; Oncology, Experimental; Patients; Stem cells; Survival analysis; Thermal cycling; Taiwan
• ISSN: 2049-9450; 2049-9469
• DOI: 10.3892/mco.2023.2690

Genomic imprinting, an epigenetic mechanism that regulates gene expression from parental chromosomes, holds substantial relevance in multiple cancers, including hematopoietic malignancies. In the present study, the expression of a panel of 16 human imprinted genes in bone marrow samples from 64 patients newly diagnosed with cytogenetically normal-acute myeloid leukemia (CN-AML) were examined alongside peripheral blood samples from 85 healthy subjects. The validated findings of the present study revealed significant upregulation of seven genes [COPI coat complex subunit gamma 2 (COPG2), H19 imprinted maternally expressed transcript (H19), insulin like growth factor 2 (IGF2), PEG3 antisense RNA 1 (PEG3-AS1), DNA primase subunit 2 (PRIM2), solute carrier family 22 member 3 SLC22A3 and Zinc finger protein 215 (ZNF215)] in patients with CN-AML (P<0.001). Notably, the expression level of H19 exhibited an inverse association with the survival duration of the patients (P=0.018), establishing it as a predictive marker for two- and five-year survival in patients with CN-AML. Kaplan-Meier analysis demonstrated that patients with lower H19 expression had superior two- and five-year survival rates compared with those with higher H19 expression. The results of the present study highlighted the association between loss of imprinting and leukemogenesis in CN-AML, underscoring the significance of H19 imprinting loss as a prognostic indicator for unfavorable two- and five-year survival in CN-AML patients.