Controlled synthesis of thermoresponsive polymer via RAFT polymerization of an acrylamide containing l-proline moiety

Reversible addition–fragmentation chain transfer (RAFT) polymerization of N-acryloyl- l-proline methyl ester (A-Pro-OMe) was investigated in order to find suitable conditions to achieve controlled synthesis of amino acid-based polymers with pre-determined molecular weight, narrow polydispersity, wel...

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Bibliographic Details
Published inReactive & functional polymers Vol. 67; no. 10; pp. 916 - 927
Main Authors Mori, Hideharu, Iwaya, Hideyuki, Endo, Takeshi
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 01.10.2007
Elsevier Science
Subjects
Acrylamide
Amino acid
Applied sciences
Exact sciences and technology
Organic polymers
Physicochemistry of polymers
Polymerization
Preparation, kinetics, thermodynamics, mechanism and catalysts
Reversible addition–fragmentation chain transfer (RAFT) polymerization
Thermoresponsive polymer
Acrylamide
Amino acid
Thermoresponsive polymer
Reversible addition–fragmentation chain transfer (RAFT) polymerization
Reversible addition-fragmentation chain transfer (RAFT) polymerization
Living polymer
Dithioester
Experimental study
Acrylamide derivative polymer
Chemical reaction kinetics
Optimization
Solution polymerization
Operating conditions
Cloud point
Free radical polymerization
Chain transfer
Preparation
Aqueous solution
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Summary:Reversible addition–fragmentation chain transfer (RAFT) polymerization of N-acryloyl- l-proline methyl ester (A-Pro-OMe) was investigated in order to find suitable conditions to achieve controlled synthesis of amino acid-based polymers with pre-determined molecular weight, narrow polydispersity, well-defined chain end structure, and characteristic thermoresponsive property. The effect of various parameters, such as chain transfer agent (CTA)/initiator ratio, solvent, and temperature, on RAFT polymerization of A-Pro-OMe was examined using benzyl dithiobenzoate as a CTA. Chain-end structure of the resulting poly(A-Pro-OMe) was confirmed by 1H NMR analysis, MALDI-TOF mass spectroscopy, and chain extension experiment. Thermally induced phase separation behaviors of poly(A-Pro-OMe)s prepared by RAFT and conventional free radical polymerizations were also studied in aqueous solution.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1381-5148
DOI:10.1016/j.reactfunctpolym.2007.05.016