A new phenolic glycoside from Lindera nacusua

• Published in: Natural product research Vol. 31; no. 8; pp. 896 - 901
• Main Authors: Lei, Jie-Ping, Wei, Guo-Qing, Yuan, Juan-Juan, Tan, Kang-Zhi, Chen, Qiao-Yu, Zhang, Tao, Ma, Chao-Ying, Jiang, He-Zhong
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 18.04.2017; Taylor & Francis Ltd
• Subjects: Anthraquinones; Anticancer properties; antineoplastic activity; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; Biotechnology; Cell Line, Tumor; Cell lines; chemical composition; Chemical compounds; chemical structure; cytotoxicity; Drug Screening Assays, Antitumor - methods; Glycosides; Glycosides - chemistry; Glycosides - isolation & purification; Glycosides - pharmacology; HL-60 Cells; Humans; In vitro methods and tests; Inhibitory Concentration 50; Lindera; Lindera - chemistry; Lindera nacusua; Molecular Structure; Monosaccharides - chemistry; Monosaccharides - isolation & purification; Monosaccharides - pharmacology; Phenolic compounds; phenolic glycoside; Phenols; Phenols - chemistry; Phenols - pharmacology; Plant Stems - chemistry; spectroscopy; γ-butanolide; cytotoxicity; phenolic glycoside; Lindera nacusua; γ-butanolide
• ISSN: 1478-6419; 1478-6427; 1478-6427
• DOI: 10.1080/14786419.2016.1253078

The present study was designed to investigate the chemical constituents of Lindera nacusua and their antitumor activities. A new phenolic glycoside, namely 1-O-3-hydroxyphenyl-5-methoxyphenol-(6′-O-vanilloyl)-β-d-glucopyranoside (1), together with five known phenolic glycosides (2-6), two anthraquinones (7, 8) and two γ-butanolides (9, 10), was isolated, and its structure was elucidated by spectroscopic and chemical methods. Compounds 1-10 were screened for their in vitro cytotoxicities against HL-60, SMMC-7721, A549, MCF-3 and SW480 cell lines by the MTS method. Compounds 9 and 10 showed moderate cytotoxicities with IC 50 values ranging from 17.40 to 35.21 μM.