Clinicopathologic Study of Leptomeningeal Carcinomatosis Involving the Temporal Bone

• Published in: Annals of otology, rhinology & laryngology Vol. 106; no. 8; pp. 674 - 679
• Main Authors: Imamura, Shun-Ichi, Imamura, Mayumi, Nozawa, Izuru, Murakami, Yoshihiko
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.08.1997; Annals Publishing Compagny; SAGE PUBLICATIONS, INC
• Subjects: Aged; Biological and medical sciences; Carcinoma, Transitional Cell - complications; Carcinoma, Transitional Cell - pathology; Carcinoma, Transitional Cell - secondary; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology; Facial Paralysis - etiology; Hearing Loss, Sensorineural - etiology; Humans; Kidney Neoplasms - pathology; Male; Medical sciences; Meningeal Neoplasms - complications; Meningeal Neoplasms - pathology; Meningeal Neoplasms - secondary; Otorhinolaryngology. Stomatology; Skull Neoplasms - pathology; Skull Neoplasms - secondary; Temporal Bone - pathology; Tumors; temporal bone histopathology; temporal bone metastasis; bilateral sudden sensorineural hearing loss; facial paralysis; Human; Nervous system diseases; Carcinoma; Temporal bone; Motor system disorder; Facial paralysis; Auditory disorder; Bilateral; Male; Facial nerve; Sudden; Malignant tumor; Transitional cell carcinoma; Metastasis; Case study; Cranial nerve disease; Pelvic cavity; ENT disease; Adult; Complication; Leptomeninge; Perception hearing loss; Bibliographic review
• ISSN: 0003-4894; 1943-572X
• DOI: 10.1177/000348949710600811

The temporal bone pathology of a 71-year-old man with bilateral sensorineural hearing loss and facial paralysis caused by diffuse metastatic leptomeningeal carcinomatosis is described. The origin of this malignant disease was an extremely rare entity, a transitional cell carcinoma of the renal pelvis. Histopathologic study of the temporal bone demonstrated that tumor cells filled the internal auditory meatus, infiltrated into the Rosenthal's canals, and reached the scala tympani of the basal turn of the bilateral cochleas. The vestibulocochlear nerve and facial nerve trunks in the internal auditory meatus had been destroyed by the bilateral tumor invasion. Case reports of temporal bone metastases of leptomeningeal carcinomatosis published since 1965 were reviewed. In leptomeningeal carcinomatosis, it is suggested that tumor cells infiltrate the internal auditory meatus of both ears simultaneously from the cerebrospinal fluid, involving the seventh and eighth nerve trunks, and then cause bilateral sensorineural hearing loss and facial paralysis.