Comparison of efficacy and toxicity of short-course carbon ion radiotherapy for hepatocellular carcinoma depending on their proximity to the porta hepatis

• Published in: Radiotherapy and oncology Vol. 96; no. 2; pp. 231 - 235
• Main Authors: Imada, Hiroshi, Kato, Hirotoshi, Yasuda, Shigeo, Yamada, Shigeru, Yanagi, Takeshi, Kishimoto, Riwa, Kandatsu, Susumu, Mizoe, Jun-etsu, Kamada, Tadashi, Yokosuka, Osamu, Tsujii, Hirohiko
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.08.2010
• Subjects: Adult; Aged; Aged, 80 and over; Carbon ion; Carbon Radioisotopes - therapeutic use; Carcinoma, Hepatocellular - radiotherapy; Female; Hematology, Oncology and Palliative Medicine; Hepatocellular carcinoma; Humans; Ions - therapeutic use; Liver Neoplasms - radiotherapy; Male; Middle Aged; Porta hepatis; Portal Vein - injuries; Portal Vein - radiation effects; Radiotherapy; Retrospective Studies; Treatment Outcome; Hepatocellular carcinoma; Carbon ion; Porta hepatis; Radiotherapy
• ISSN: 0167-8140; 1879-0887
• DOI: 10.1016/j.radonc.2010.05.019

Abstract Background and purpose To compare the efficacy and toxicity of short-course carbon ion radiotherapy (C-ion RT) for patients with hepatocellular carcinoma (HCC) in terms of tumor location: adjacent to the porta hepatis or not. Materials and methods The study consisted of 64 patients undergoing C-ion RT of 52.8 GyE in four fractions between April 2000 and March 2003. Of these patients, 18 had HCC located within 2 cm of the main portal vein (porta hepatis group) and 46 patients had HCC far from the porta hepatis (non-porta hepatis group). We compared local control, survival, and adverse events between the two groups. Results The 5-year overall survival and local control rates were 22.2% and 87.8% in the porta hepatis group and 34.8% and 95.7% in the non-porta hepatis group, respectively. There were no significant differences ( P = 0.252, P = 0.306, respectively). Further, there were no significant differences in toxicities. Biliary stricture associated with C-ion RT did not occur. Conclusions Excellent local control was obtained independent of tumor location. The short-course C-ion RT of 52.8 GyE in four fractions appears to be an effective and safe treatment modality in the porta hepatis group just as in the non-porta hepatis group.