Nitrate levels in community drinking waters and risk of IDDM. An ecological analysis
Nitrate levels in community drinking waters and risk of IDDM. An ecological analysis. J N Kostraba , E C Gay , M Rewers and R F Hamman Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver 80262. Abstract OBJECTIVE--To investigate whether higher IDDM...
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Published in | Diabetes care Vol. 15; no. 11; pp. 1505 - 1508 |
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Main Authors | , , , |
Format | Journal Article Conference Proceeding |
Language | English |
Published |
Alexandria, VA
American Diabetes Association
01.11.1992
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Subjects | |
Online Access | Get full text |
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Summary: | Nitrate levels in community drinking waters and risk of IDDM. An ecological analysis.
J N Kostraba ,
E C Gay ,
M Rewers and
R F Hamman
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver 80262.
Abstract
OBJECTIVE--To investigate whether higher IDDM incidence rates occurred in areas with high nitrate levels in their potable
water supplies. RESEARCH DESIGN AND METHODS--Incidence rates for the 63 counties in Colorado were calculated using the Colorado
IDDM Registry of children diagnosed < 18 yr of age between 1978 and 1988 (n = 1280). A weighted average of the nitrate levels
from each water district within each county was calculated using data collected by the Colorado Department of Health between
1984 and 1988. RESULTS--The rs between nitrate levels and IDDM incidence was 0.26 (P = 0.03). After controlling for differences
in ethnicity, counties with water nitrate levels in the third tertile (0.77-8.2 mg/L) had a significantly increased risk of
IDDM compared with those in the first tertile (0.0-0.084 mg/L) (rp = 0.29, P = 0.02). CONCLUSIONS--This ecological analysis
suggests that low-level nitrate exposure through drinking water may play a role in the etiology of IDDM, perhaps as a promoter
through the generation of free radicals. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0149-5992 1935-5548 |
DOI: | 10.2337/diacare.15.11.1505 |