The First Case of Granulicatella adiacens Identified from a Resected Heart Valve by Next Generation Sequencing (NGS) in Poland

• Published in: Pathogens (Basel) Vol. 11; no. 3; p. 295
• Main Authors: Podgórska, Anna, Kordybach-Prokopiuk, Maria, Jaworska-Wilczyńska, Maria, Hoffman, Piotr, Biernacka, Katarzyna, Kuśmierski, Krzysztof, Kuthan, Robert, Hryniewiecki, Tomasz, Lutyńska, Anna
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.02.2022; MDPI
• Subjects: Antibiotics; Aorta; Aortic valve; Bacteria; Cardiology; Case Report; Chills; Complications; Congenital anomalies; Dyspnea; Endocarditis; Fever; Granulicatela adiacens; Granulicatella adiacens; Heart; Heart valves; infective endocarditis; Metagenomics; Microorganisms; Next-generation sequencing; next-generation sequencing (NGS); nutritionally variant streptococci (NVS); Oral cavity; Pain; Respiration; Ribosomal DNA; rRNA 16S; Software; Taxonomy; Weight loss; Poland; France; United States > US; Germany; nutritionally variant streptococci (NVS); aortic valve; infective endocarditis; Granulicatela adiacens; next-generation sequencing (NGS)
• ISSN: 2076-0817; 2076-0817
• DOI: 10.3390/pathogens11030295

In this report, we describe the course and successful treatment of a case of complicated infective endocarditis (IE). A patient presented with a high-grade, irregular fever with chills lasting at least 2 months along with dyspnoea, chest pain, fatigue, weight loss, and night sweats during the previous 3 months. As well as cardiac congenital disorders, he was found to have infective aortic valve endocarditis, presumably transmitted from the oral cavity niche. Validated metagenomic 16S rDNA next generation sequencing was used to perform taxonomic identification, allowing for specific adequate antibiotic therapy instead of empiric therapy. This paper highlights the critical role of rapid taxonomic identification of nutritionally variant streptococci and the benefit of proper IE treatment in avoiding relapses or fatal complications.