Estimating relative bioavailability of soil lead in the mouse

Lead (Pb) in soil is an important exposure source for children. Thus, determining bioavailability of Pb in soil is critical in evaluating risk and selecting appropriate strategies to minimize exposure. A mouse model was developed to estimate relative bioavailability of Pb in NIST SRM 2710a (Montana...

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Published inJournal of Toxicology and Environmental Health, Part A Vol. 79; no. 24; pp. 1179 - 1182
Main Authors Bradham, Karen D., Green, William, Hayes, Hunter, Nelson, Clay, Alava, Pradeep, Misenheimer, John, Diamond, Gary L., Thayer, William C., Thomas, David J.
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.01.2016
Taylor & Francis Ltd
Subjects
Animals
Bioavailability
Biological Availability
Environmental Monitoring
Estimates
Exposure
Female
Lead (metal)
Lead - pharmacokinetics
Mice
Mice, Inbred C57BL
Public health
Risk
Risk Assessment
Soil Pollutants - pharmacokinetics
Strategy
Tissue Distribution
Toxicity
Toxicology
USA, Montana
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Summary:Lead (Pb) in soil is an important exposure source for children. Thus, determining bioavailability of Pb in soil is critical in evaluating risk and selecting appropriate strategies to minimize exposure. A mouse model was developed to estimate relative bioavailability of Pb in NIST SRM 2710a (Montana 1 Soil). Based on Pb levels in tissues, the mean relative bioavailability of this metal in this soil was 0.5. Estimates of relative bioavailabilities derived from mouse compared favorably with those obtained in juvenile swine. The mouse model is thus an efficient and inexpensive method to obtain estimates of relative bioavailability of soil Pb.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1528-7394
1087-2620
2381-3504
DOI:10.1080/15287394.2016.1221789