Biogenic Synthesis of Ag Nanoparticles of 18.27 nm by Zanthozylum armatum and Determination of Biological Potentials

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 4; p. 1166
• Main Authors: Riaz, Muhammad, Altaf, Muhammad, Ahmad, Pervaiz, Khandaker, Mayeen Uddin, Osman, Hamid, Eed, Emad M, Shakir, Yasmeen
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09.02.2022; MDPI
• Subjects: AgNPs; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; antibacterial; Antibiotics; Antimicrobial agents; antioxidant; Antioxidants; Bark; Biosynthesis; Drug development; Escherichia coli - growth & development; Flavonoids; Functional groups; green synthesis; Herbal medicine; Lead compounds; Medicinal plants; Metal Nanoparticles - chemistry; Microorganisms; Nanomaterials; Nanoparticles; Nanotechnology; Phenolic compounds; Phenols; Plant diseases; Plant extracts; Plant Extracts - chemistry; Pseudomonas aeruginosa - growth & development; Silver; Silver - chemistry; Silver - pharmacology; Spectroscopy, Fourier Transform Infrared; Stabilizers (agents); Zanthoxylum - chemistry; Zanthozylum armatum; United States > US; Pakistan; AgNPs; Zanthozylum armatum; antioxidant; antibacterial; green synthesis
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27041166

Nanotechnology has become a dire need of the current era and the green synthesis of nanoparticles offers several advantages over other methods. Nanobiotechnology is an emerging field that contributes to many domains of human life, such as the formulation of nanoscale drug systems or nanomedicine for the diagnosis and treatment of diseases. Medicinal plants are the main sources of lead compounds, drug candidates and drugs. This work reports the green synthesis of Ag nanoparticles (AgNPs) using the aqueous bark extract of which was confirmed by a UV absorption at 457 nm. XRD analysis revealed an average size of 18.27 nm and SEM showed the particles' spherical shape, with few irregularly shaped particles due to the aggregation of the AgNPs. FT-IR revealed the critical functional groups of phytochemicals which acted as reducing and stabilizing agents. The bark extract showed rich flavonoids (333 mg RE/g) and phenolic contents (82 mg GAE/g), which were plausibly responsible for its high antioxidant potency (IC = 14.61 µg/mL). Extract-loaded AgNPs exhibited the highest but equal inhibition against and (Z.I. 11.0 mm), whereas methanolic bark extract inhibited to a lesser extent, but equally to both pathogens (Z.I. 6.0 mm). The aqueous bark extract inhibited (Z.I. 9.0 mm) and (Z.I. 6.0 mm) These findings-especially the biosynthesis of spherical AgNPs of 18.27 nm-provide promise for further investigation and for the development of commercializable biomedical products.