Genetic and Epigenetic Mechanisms of Psoriasis

Psoriasis is a disease involving the innate and adaptative components of the immune system, and it is triggered by environmental factors in genetically susceptible individuals. However, its physiopathology is not fully understood yet. Recent technological advances, especially in genome and epigenome...

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Bibliographic Details
Published inGenes Vol. 14; no. 8; p. 1619
Main Authors Mateu-Arrom, Laura, Puig, Lluis
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.08.2023
MDPI
Subjects
Antigen presentation
Chronic illnesses
Disease
Drug development
Endoplasmic reticulum
Environmental factors
Epigenetic inheritance
Epigenetics
Gene loci
Genomes
Genomics
Immune system
Immunoglobulins
Immunosuppressive agents
Kinases
Pathogenesis
Peptides
Psoriasis
Psoriatic arthritis
Quality of life
Review
Signal transduction
Skin diseases
T cell receptors
Tumor necrosis factor-TNF
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Summary:Psoriasis is a disease involving the innate and adaptative components of the immune system, and it is triggered by environmental factors in genetically susceptible individuals. However, its physiopathology is not fully understood yet. Recent technological advances, especially in genome and epigenome-wide studies, have provided a better understanding of the genetic and epigenetic mechanisms to determine the physiopathology of psoriasis and facilitate the development of new drugs. This review intends to summarize the current evidence on genetic and epigenetic mechanisms of psoriasis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:2073-4425
2073-4425
DOI:10.3390/genes14081619