Eye color and the prediction of complex phenotypes from genotypes

Predicting complex human phenotypes from genotypes has recently gained tremendous interest in the emerging field of consumer genomics, particularly in light of attempting personalized medicine [1,2]. So far, however, this approach has not been shown to be accurate, thus limiting its practical applic...

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Bibliographic Details
Published inCurrent biology Vol. 19; no. 5; pp. R192 - R193
Main Authors Liu, Fan, van Duijn, Kate, Vingerling, Johannes R., Hofman, Albert, Uitterlinden, André G., Janssens, A. Cecile J.W., Kayser, Manfred
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 10.03.2009
Subjects
Area Under Curve
European Continental Ancestry Group - genetics
Eye Color
Genotype
Humans
Models, Genetic
Phenotype
Polymorphism, Single Nucleotide
Regression Analysis
Sensitivity and Specificity
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Summary:Predicting complex human phenotypes from genotypes has recently gained tremendous interest in the emerging field of consumer genomics, particularly in light of attempting personalized medicine [1,2]. So far, however, this approach has not been shown to be accurate, thus limiting its practical applications [3,4]. Here, we used human eye (iris) color of Europeans as an empirical example to demonstrate that highly accurate genetic prediction of complex human phenotypes is feasible. Moreover, the six DNA markers we identified as major eye color predictors will be valuable in forensic studies.
Bibliography:SourceType-Other Sources-1
ObjectType-Article-2
content type line 63
ObjectType-Correspondence-1
ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2009.01.027