Immunopathogenesis of inflammatory bowel disease and mechanisms of biological therapies

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract with a multifactorial pathophysiology. Full comprehension of IBD pathology is still out of reach and, therefore, treatment is far from ideal. Nevertheless, components involved in IBD pathogenesis includ...

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Bibliographic Details
Published inScandinavian journal of gastroenterology Vol. 53; no. 4; p. 379
Main Authors Ahluwalia, Bani, Moraes, Luiza, Magnusson, Maria K, Öhman, Lena
Format Journal Article
LanguageEnglish
Published England 03.04.2018
Subjects
biological therapies
immunopathogenesis
dysregulated immune response
IBD
ulcerative colitis
chronic inflammation
Crohn’s disease
dysbiosis
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Summary:Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract with a multifactorial pathophysiology. Full comprehension of IBD pathology is still out of reach and, therefore, treatment is far from ideal. Nevertheless, components involved in IBD pathogenesis including environmental, genetic, microbial, and immunological factors are continuously being investigated and the improved knowledge contributes to the development of new therapies. In this article we review the aspects of the immunopathogenesis of IBD, with focus on mucosal immunity, and discuss mechanisms of action for current and emerging biological therapies.
ISSN:1502-7708
DOI:10.1080/00365521.2018.1447597