Dominant Negative TRAF3 Variant With Recurrent Mycobacterium abscessus Infection and Bronchiectasis

Abstract Host factors leading to pulmonary nontuberculous mycobacteria (PNTM) disease are poorly understood compared with disseminated NTM disease, which is linked to the interleukin 12–interferon gamma signaling pathway. We investigated the tumor necrosis factor receptor associated factor 3 (TRAF3)...

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Published inOpen forum infectious diseases Vol. 9; no. 8; p. ofac379
Main Authors Liew, Mei Fong, Lim, Hui Fang, Liang, Mui Cheng, Lim, Ives, Tan, Zhaohong, Tan, Rachel Ying Min, Sam, Qi Hui, Soe, Win Mar, Tay, Sen Hee, Xu, Shengli, Chang, Matthew Wook, Foo, Roger, Soong, Tuck Wah, Ravikumar, Sharada, Chai, Louis Yi Ann
Format Journal Article
LanguageEnglish
Published Oxford University Press 01.08.2022
Subjects
Brief Report
nontuberculous mycobacteria
pulmonary infection
immunocompromised host
transfection
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Summary:Abstract Host factors leading to pulmonary nontuberculous mycobacteria (PNTM) disease are poorly understood compared with disseminated NTM disease, which is linked to the interleukin 12–interferon gamma signaling pathway. We investigated the tumor necrosis factor receptor associated factor 3 (TRAF3) R338W variant in a patient with recurrent PNTM infection, demonstrating TRAF3- and TNF-α-deficient phenotypes via ex vivo immune and cloning-transfection cellular studies.
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Potential conflicts of interest. The authors declare that they have no conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.
Mei Fong Liew, Hui Fang Lim, Sharada Ravikumar and Louis Yi Ann Chai shares equal authorship.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofac379