Ionic liquid supported organotin reagents to prepare molecular imaging and therapy agents

Efficiency of ionic liquid supported organotin reagents in halodemetalation reaction has been investigated. High radiochemical yields of astatinated and iodinated compounds have been obtained using simple work-up procedure. This methodology represents a straightforward approach for the preparation o...

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Published inOrganic & biomolecular chemistry Vol. 14; no. 6; pp. 2121 - 2126
Main Authors Rajerison, Holisoa, Faye, Djibril, Roumesy, Aurelia, Louaisil, Nicolas, Boeda, Fabien, Faivre-Chauvet, Alain, Gestin, Jean-Francois, Legoupy, Stephanie
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2016
Royal Society of Chemistry
Subjects
Cancer
Chemistry
Chemistry, Organic
Iodine Radioisotopes - chemistry
Iodine Radioisotopes - therapeutic use
Ionic Liquids - chemistry
Life Sciences
Molecular Imaging - methods
Molecular Structure
Nuclear Medicine
Organotin Compounds - chemistry
Physical Sciences
Radioimmunoassay
Radiopharmaceuticals - chemical synthesis
Radiopharmaceuticals - chemistry
Radiopharmaceuticals - therapeutic use
Science & Technology
CROSS-COUPLING REACTIONS
ASTATINATION
AFFINITY
STRATEGY
TIN REAGENTS
N-SUCCINIMIDYL
ARYL-FLUORIDES
PROTEINS
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Summary:Efficiency of ionic liquid supported organotin reagents in halodemetalation reaction has been investigated. High radiochemical yields of astatinated and iodinated compounds have been obtained using simple work-up procedure. This methodology represents a straightforward approach for the preparation of molecular imaging and therapy agents in nuclear medicine.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob02459e