Targeting Mitochondria and Oxidative Stress in Cancer- and Chemotherapy-Induced Muscle Wasting

• Published in: Antioxidants & redox signaling Vol. 38; no. 4-6; p. 352
• Main Authors: Huot, Joshua R, Baumfalk, Dryden, Resendiz, Aridai, Bonetto, Andrea, Smuder, Ashley J, Penna, Fabio
• Format: Journal Article
• Language: English
• Published: United States 01.02.2023
• Subjects: Antineoplastic Agents - adverse effects; Cachexia - etiology; Humans; Mitochondria - metabolism; Muscle, Skeletal - metabolism; Muscular Atrophy - chemically induced; Neoplasms - metabolism; Oxidative Stress; wasting; cancer; antioxidants; chemotherapy; nutraceuticals

Cancer is frequently associated with the early appearance of cachexia, a multifactorial wasting syndrome. If not present at diagnosis, cachexia develops either as a result of tumor progression or as a side effect of anticancer treatments, especially of standard chemotherapy, eventually representing...