Special Considerations in Classification and Workup of Endometrial Carcinomas

• Published in: Archives of pathology & laboratory medicine (1976) Vol. 148; no. 4; pp. 390 - 397
• Main Authors: Rottmann, Douglas A, Skala, Stephanie L
• Format: Journal Article
• Language: English
• Published: United States College of American Pathologists 01.04.2024
• Subjects: Analysis; Body mass index; Cancer; Cancer therapies; Carcinoma; Care and treatment; Chemotherapy; Classification; Copy number; Diagnosis; Differential diagnosis; DNA biosynthesis; Endometrial cancer; Endometrium; Epithelium; Estrogen receptors; Exonuclease; GATA-3 protein; Glands; Hyperplasia; Immunohistochemistry; K-Ras protein; Metaplasia; Microsatellite instability; Mismatch repair; Molecular dynamics; Mutation; p53 Protein; Patients; Pembrolizumab; Phenotypes; Progesterone; Proofreading; PTEN protein; Radiation; Stains & staining; Tumors; Uterine cancer; Vacuoles; Yeast; United States; Michigan
• ISSN: 0003-9985; 1543-2165; 1543-2165
• DOI: 10.5858/arpa.2023-0098-RA

A variety of uncommon malignant endometrial tumors can be challenging to diagnose because of overlapping morphology with more common entities. In some cases, immunohistochemical stains and/or molecular testing allow for more definitive diagnosis or prognostication. To review classic morphologic features of uncommon endometrial tumors, pathologic features of these tumors and their mimics, and the evidence for use of immunohistochemistry and molecular testing in the diagnosis of these tumors. University of Michigan (Ann Arbor) cases and review of pertinent literature about each entity. Although each of these uncommon endometrial tumors has morphologic mimics, key histologic features, immunohistochemical stains, and molecular testing allow for accurate classification.