Body size modifies the relationship between maternal serum 25-hydroxyvitamin D concentrations and gestational diabetes in high-risk women

• Published in: European journal of clinical nutrition Vol. 72; no. 3; pp. 460 - 463
• Main Authors: Valkama, Anita J, Meinilä, Jelena M, Koivusalo, Saila B, Lindström, Jaana, Rönö, Kristiina, Tiitinen, Aila E, Stach-Lempinen, Beata, Kautiainen, Hannu J, Viljakainen, Heli, Andersson, Sture, Eriksson, Johan G
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.03.2018
• Subjects: 25-Hydroxyvitamin D; Adult; Body mass; Body size; Body Size - physiology; Development and progression; Diabetes; Diabetes mellitus; Diabetes research; Diabetes, Gestational - blood; Diabetes, Gestational - epidemiology; Female; Gestational diabetes; Health aspects; Health risk assessment; Health risks; Humans; Obesity; Pregnancy; Pregnant women; Prospective Studies; Risk; Risk factors; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D deficiency; Women
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/s41430-017-0010-0

Obesity increases the risk of low 25-hydroxyvitamin D (25(OH)D) concentrations and gestational diabetes (GDM). We explored whether the association between GDM and change in 25(OH)D concentrations measured in the first (7-18 wk) and second (20-27 wk) trimesters of pregnancy is dependent on maternal BMI. The study was a prospective study of 219 women with BMI of ≥30 kg/m , a history of GDM, or both. The participants were stratified by first-trimester BMI: BMI of <25.0, 25.0-29.9, 30.0-34.9, and ≥35 kg/m . In the BMI group ≥35 kg/m , those who did not develop GDM during the follow-up showed higher increase in serum 25(OH)D concentrations compared with women who developed GDM (43.2 vs. 11.5%; P < 0.001). No associations between 25(OH)D concentrations and GDM were observed in other BMI groups. These findings give an important aspect of the role of maternal body size in the association between vitamin D and GDM in high-risk women.