Development and optimization of a noncontact optical device for online monitoring of jaundice in human subjects

• Published in: Journal of biomedical optics Vol. 20; no. 6; p. 067001
• Main Authors: Polley, Nabarun, Saha, Srimoyee, Singh, Soumendra, Adhikari, Aniruddha, Das, Sukhen, Choudhury, Bhaskar Roy, Pal, Samir Kumar
• Format: Journal Article
• Language: English
• Published: United States Society of Photo-Optical Instrumentation Engineers 01.06.2015
• Subjects: Adult; Bilirubin - analysis; Conjunctiva - pathology; Equipment Design; Humans; Jaundice - diagnosis; Jaundice - pathology; Linear Models; Middle Aged; Monitoring, Physiologic - instrumentation; Monitoring, Physiologic - methods; Optical Imaging - instrumentation; Optical Imaging - methods; Reproducibility of Results; Software; diagnosis; software development; noncontact optical method; jaundice detection; conjunctiva; diffused reflection
• ISSN: 1083-3668; 1560-2281; 1560-2281
• DOI: 10.1117/1.JBO.20.6.067001

Jaundice is one of the notable markers of liver malfunction in our body, revealing a significant rise in the concentration of an endogenous yellow pigment bilirubin. We have described a method for measuring the optical spectrum of our conjunctiva and derived pigment concentration by using diffused reflection measurement. The method uses no prior model and is expected to work across the races (skin color) encompassing a wide range of age groups. An optical fiber-based setup capable of measuring the conjunctival absorption spectrum from 400 to 800 nm is used to monitor the level of bilirubin and is calibrated with the value measured from blood serum of the same human subject. We have also developed software in the LabVIEW platform for use in online monitoring of bilirubin levels in human subjects by nonexperts. The results demonstrate that relative absorption at 460 and 600 nm has a distinct correlation with that of the bilirubin concentration measured from blood serum. Statistical analysis revealed that our proposed method is in agreement with the conventional biochemical method. The innovative noncontact, low-cost technique is expected to have importance in monitoring jaundice in developing/underdeveloped countries, where the inexpensive diagnosis of jaundice with minimally trained manpower is obligatory.